Scholarlink

<p>The present investigation employed a post-impregnation technique to evaluate the sorptive capacity of the synthesized KIT-6 surface for drug loading from an aqueous solution. Silica KIT-6 was selected as the model adsorbent, with juglone utilized as the model drug for studying its adsorption and release behaviour. The drug loading process was conducted under standard conditions. The materials were characterized both prior to and following drug loading using various techniques, including FTIR, BET analysis, TGA, FESEM-EDX, HRTEM, WA-XRD, and LA-XRD. The solubility and release characteristics of the loaded materials were systematically assessed. Notably, juglone exhibited an entrapment efficiency of 95% in KIT-. 6 and 58% in amine-functionalized KIT-6. Subsequent loading of JUG onto both KIT-6 and amine-functionalized KIT-6 resulted in further decreases in surface area (176 m<sup>2</sup>/g), pore volume (0.20 cm<sup>3</sup>/g), and a decrement in the pore size dissemination to smaller diameters (4.6&#xa0;nm). Amine-functionalized KIT-6 micro-spheres were found to show a significantly slower drug release rate 20 ± 0.43 than pure KIT-6, which should facilitate drug delivery control over a longer time period. The KIT-6 carrier demonstrated superior drug loading capacity and dissolution profile, indicating its potential to enhance juglone bioavailability. This study presents newly developed formulations that incorporate juglone into KIT-6 and amine-functionalized KIT-6, highlighting their potential as effective delivery systems for juglone. These formulations offer enhanced drug bioavailability and improved safety profiles, suggesting their potent role in drug delivery applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Development and assessment of amine-functionalized KIT-6 for In Vitro drug delivery using Juglone as the therapeutic agent

  • 期刊论文

  • 发表日期：

    2025年12月22日

查看全文
  • Priya Malik,
  • Sushma Kumari,
  • Pooja Kumari,
  • Munish Ahuja,
  • Surender Duhan,
  • Ajay Kumar Sharma,
  • Gyanendra Sheoran

摘要

The present investigation employed a post-impregnation technique to evaluate the sorptive capacity of the synthesized KIT-6 surface for drug loading from an aqueous solution. Silica KIT-6 was selected as the model adsorbent, with juglone utilized as the model drug for studying its adsorption and release behaviour. The drug loading process was conducted under standard conditions. The materials were characterized both prior to and following drug loading using various techniques, including FTIR, BET analysis, TGA, FESEM-EDX, HRTEM, WA-XRD, and LA-XRD. The solubility and release characteristics of the loaded materials were systematically assessed. Notably, juglone exhibited an entrapment efficiency of 95% in KIT-. 6 and 58% in amine-functionalized KIT-6. Subsequent loading of JUG onto both KIT-6 and amine-functionalized KIT-6 resulted in further decreases in surface area (176 m2/g), pore volume (0.20 cm3/g), and a decrement in the pore size dissemination to smaller diameters (4.6 nm). Amine-functionalized KIT-6 micro-spheres were found to show a significantly slower drug release rate 20 ± 0.43 than pure KIT-6, which should facilitate drug delivery control over a longer time period. The KIT-6 carrier demonstrated superior drug loading capacity and dissolution profile, indicating its potential to enhance juglone bioavailability. This study presents newly developed formulations that incorporate juglone into KIT-6 and amine-functionalized KIT-6, highlighting their potential as effective delivery systems for juglone. These formulations offer enhanced drug bioavailability and improved safety profiles, suggesting their potent role in drug delivery applications.