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<p>Hemoperfusion is a promising alternative to hemodialysis, particularly for removing protein-bound uremic toxins such as p-Cresol, which are poorly eliminated by conventional dialysis due to their strong affinity to plasma proteins. However, current adsorbents often suffer from limited adsorption efficiency and poor biocompatibility. This study presents the development of α-mangostin-loaded silica nanoparticles to enhance both adsorption performance and biocompatibility for potential blood purification applications. Mesoporous silica nanoparticles (15–25&#xa0;nm) were synthesized and functionalized with 0.5 and 1.5 wt% α-mangostin. Their performance was evaluated through p-Cresol adsorption and nitric oxide scavenging assays. At an initial p-Cresol concentration of 250&#xa0;mg/L, the adsorption capacities of pure α-mangostin, silica, silica/0.5mangostin, and silica/1.5mangostin were 15.87, 197.67, 179.49, and 185.67&#xa0;mg/g, respectively. The incorporation of α-mangostin preserved silica’s adsorption capacity while enhancing antioxidant properties. Compared to plain silica, the α-mangostin-loaded nanoparticles increased clotting time by 21.5% and reduced reactive oxygen species by 36%, indicating improved biocompatibility. These results suggest that α-mangostin-loaded silica nanoparticles are promising candidates for multifunctional adsorbents with enhanced biocompatibility for blood purification.</p>

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Development of α-mangostin-loaded silica nanoparticles with enhanced protein-bound uremic toxin adsorption and biocompatibility

  • 期刊论文

  • 发表日期：

    2025年8月11日

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  • Sumarni Mansur,
  • Muhammad Nidzhom Zainol Abidin

摘要

Hemoperfusion is a promising alternative to hemodialysis, particularly for removing protein-bound uremic toxins such as p-Cresol, which are poorly eliminated by conventional dialysis due to their strong affinity to plasma proteins. However, current adsorbents often suffer from limited adsorption efficiency and poor biocompatibility. This study presents the development of α-mangostin-loaded silica nanoparticles to enhance both adsorption performance and biocompatibility for potential blood purification applications. Mesoporous silica nanoparticles (15–25 nm) were synthesized and functionalized with 0.5 and 1.5 wt% α-mangostin. Their performance was evaluated through p-Cresol adsorption and nitric oxide scavenging assays. At an initial p-Cresol concentration of 250 mg/L, the adsorption capacities of pure α-mangostin, silica, silica/0.5mangostin, and silica/1.5mangostin were 15.87, 197.67, 179.49, and 185.67 mg/g, respectively. The incorporation of α-mangostin preserved silica’s adsorption capacity while enhancing antioxidant properties. Compared to plain silica, the α-mangostin-loaded nanoparticles increased clotting time by 21.5% and reduced reactive oxygen species by 36%, indicating improved biocompatibility. These results suggest that α-mangostin-loaded silica nanoparticles are promising candidates for multifunctional adsorbents with enhanced biocompatibility for blood purification.