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<p>Micro tomography emerges as a dependable, efficient, and non-destructive technique compared to traditional methods for assessing micro architectural characteristics in scaffolds. Chitosan, gelatin, and monetite [dicalcium phosphate anhydrous, DCPA] containing scaffolds with tailored structures and properties have great potential for bone repair and regeneration. Scaffolds were prepared from the viscous slurry containing chitosan, gelatin, and synthesized monetite nanoparticles using the freeze-drying method. The prepared scaffold showed significantly high interconnected porosity with pore size varying between 90–390&#xa0;µm. Incorporating the monetite particles led to an increase in the stiffness diminishing the degree of hydrophilic sites in the polymer matrix resulting in the reduction in the average pore size, porosity, swelling capacity, and biodegradation rate of the fabricated composite scaffolds. The micro architectural features were examined, with a focus on quantifying various parameters such as pore size, shape, orientation, interconnectivity, and fractal analysis. All the scaffolds exhibited a favorable porosity range between 77 to 88%, a degree of pore anisotropy varying between 1.5 to 2, and a fractal dimension varying between 2.4 to 2.8, making them suitable for the applications in bone tissue engineering (BTE). The scaffolds possessed notable macro porosity alongside favorable pore architecture and interconnectivity. The quantification of diverse parameters yielded promising outcomes, highlighting micro tomography's efficacy as a tool for studying and quantifying pore characteristics in BTE scaffolds.</p>

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Quantitative analysis of reinforcement of nano-sized monetite particles on chitosan/gelatin 3D porous scaffolds using the micro-CT technique

  • 期刊论文

  • 发表日期：

    2025年5月7日

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  • Yogendra Pratap Singh,
  • Sudip Dasgupta,
  • Ashish Kumar Agrawal,
  • Rakesh Bhaskar

摘要

Micro tomography emerges as a dependable, efficient, and non-destructive technique compared to traditional methods for assessing micro architectural characteristics in scaffolds. Chitosan, gelatin, and monetite [dicalcium phosphate anhydrous, DCPA] containing scaffolds with tailored structures and properties have great potential for bone repair and regeneration. Scaffolds were prepared from the viscous slurry containing chitosan, gelatin, and synthesized monetite nanoparticles using the freeze-drying method. The prepared scaffold showed significantly high interconnected porosity with pore size varying between 90–390 µm. Incorporating the monetite particles led to an increase in the stiffness diminishing the degree of hydrophilic sites in the polymer matrix resulting in the reduction in the average pore size, porosity, swelling capacity, and biodegradation rate of the fabricated composite scaffolds. The micro architectural features were examined, with a focus on quantifying various parameters such as pore size, shape, orientation, interconnectivity, and fractal analysis. All the scaffolds exhibited a favorable porosity range between 77 to 88%, a degree of pore anisotropy varying between 1.5 to 2, and a fractal dimension varying between 2.4 to 2.8, making them suitable for the applications in bone tissue engineering (BTE). The scaffolds possessed notable macro porosity alongside favorable pore architecture and interconnectivity. The quantification of diverse parameters yielded promising outcomes, highlighting micro tomography's efficacy as a tool for studying and quantifying pore characteristics in BTE scaffolds.