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<p>In this study, mesoporous silica nanoparticles (MSNs) were synthesized via a sol–gel process and functionalized with pH-responsive polyacrylic acid (PAA) brushes through surface-initiated atom transfer radical polymerization. The resulting nanoparticles, with an average diameter of approximately 100&#xa0;nm as determined by SEM and TEM, exhibited pH-sensitive swelling and shrinking behavior, confirmed by DLS analysis. Fourier Transform Infrared Spectroscopy (FT-IR) verified the successful conjugation of PAA through the appearance of characteristic carboxylate absorption bands. The MSNs were evaluated as nanocarriers for cisplatin (CP@MSNs-PAA) and as dual nanocarriers for cisplatin and doxorubicin (CP/DOX@MSNs-PAA), achieving high drug entrapment efficiencies (~ 98%). Drug release studies demonstrated near-complete release of cisplatin and optimized release of DOX (49.94%) under mildly acidic conditions (pH 6.5). Energy-Dispersive X-ray Spectroscopy (EDX) confirmed the effective loading and release of both drugs, as evidenced by changes in elemental composition before and after release. In vitro cytotoxicity assays indicated the biocompatibility of unloaded MSNs-PAA, while CP/DOX@MSNs-PAA exhibited significantly enhanced cytotoxic effects, highlighting the synergistic therapeutic potential of the dual drug-loaded system.</p>

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Doxorubicin and cisplatin dual-loaded mesoporous silica nanoparticles coated with polyacrylic acid brushes to enhance anticancer activities

  • 期刊论文

  • 发表日期：

    2025年2月27日

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  • Amal Siraj,
  • Anas Aljarbou,
  • Nasser B. Alsaleh,
  • Amal Alfawaz,
  • Abeer Beagan,
  • Khalid Alotaibi,
  • Abdullah Alswieleh

摘要

In this study, mesoporous silica nanoparticles (MSNs) were synthesized via a sol–gel process and functionalized with pH-responsive polyacrylic acid (PAA) brushes through surface-initiated atom transfer radical polymerization. The resulting nanoparticles, with an average diameter of approximately 100 nm as determined by SEM and TEM, exhibited pH-sensitive swelling and shrinking behavior, confirmed by DLS analysis. Fourier Transform Infrared Spectroscopy (FT-IR) verified the successful conjugation of PAA through the appearance of characteristic carboxylate absorption bands. The MSNs were evaluated as nanocarriers for cisplatin (CP@MSNs-PAA) and as dual nanocarriers for cisplatin and doxorubicin (CP/DOX@MSNs-PAA), achieving high drug entrapment efficiencies (~ 98%). Drug release studies demonstrated near-complete release of cisplatin and optimized release of DOX (49.94%) under mildly acidic conditions (pH 6.5). Energy-Dispersive X-ray Spectroscopy (EDX) confirmed the effective loading and release of both drugs, as evidenced by changes in elemental composition before and after release. In vitro cytotoxicity assays indicated the biocompatibility of unloaded MSNs-PAA, while CP/DOX@MSNs-PAA exhibited significantly enhanced cytotoxic effects, highlighting the synergistic therapeutic potential of the dual drug-loaded system.