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<p>In the present work, we have developed a facile, environmentally friendly, and efficient method for one-pot synthesis of 1,4-dihydropyridine derivatives using CuCeO<sub>2</sub> NPs as a catalyst and ethanol as a solvent from dimedone, ammonium acetate, and various aldehydes. The porous and spherical CuCeO<sub>2</sub> NPs were synthesized using a simple co-precipitation method with an average crystallite size of 7.1&#xa0;nm. CuCeO<sub>2</sub> NPs as an efficient catalyst were successfully used for the synthesis of pharmaceutically significant 1,4-dihydropyridine derivatives. Notable benefits of this approach include excellent yields, mild reaction conditions, rapid reaction time, simple workup, affordability, and reusability of catalyst.</p>

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CuCeO2 NPs: An efficient catalyst for the synthesis of 1,4-dihydropyridine derivatives

  • 期刊论文

  • 发表日期：

    2025年2月8日

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  • Shaheen A. Shaikh,
  • Vishal S. Kamble,
  • Priya A. Patil,
  • Balasaheb D. Aghav

摘要

In the present work, we have developed a facile, environmentally friendly, and efficient method for one-pot synthesis of 1,4-dihydropyridine derivatives using CuCeO2 NPs as a catalyst and ethanol as a solvent from dimedone, ammonium acetate, and various aldehydes. The porous and spherical CuCeO2 NPs were synthesized using a simple co-precipitation method with an average crystallite size of 7.1 nm. CuCeO2 NPs as an efficient catalyst were successfully used for the synthesis of pharmaceutically significant 1,4-dihydropyridine derivatives. Notable benefits of this approach include excellent yields, mild reaction conditions, rapid reaction time, simple workup, affordability, and reusability of catalyst.