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<p>MIL-125(Ti) and its many modifications have demonstrated excellent biocompatibility, indicating significant potential as a drug carrier. This study examined the delivery potential of 5-fluorouracil using MIL-125(Ti) or MIL-125(Ti)-NH<sub>2</sub>. The synthesis of the two MOFs was conducted solvothermally at a temperature of 175&#xa0;°C. This solvothermal approach yielded MOFs with distinct and clear diffraction peaks, indicating the high crystallinity of both resulting MOFs. Based on the nitrogen adsorption analysis, the surface areas for both MOFs were 712 m<sup>2</sup>/g for MIL-125(Ti) and 892 m<sup>2</sup>/g for MIL-125(Ti)-NH<sub>2</sub>. Both MOFs synthesized in this study possess micropore and small mesopore structures. In the 5-fluorouracil loading experiment, MIL-125(Ti) exhibited a maximum loading capacity of 118.7&#xa0;mg/g (47.48%), whereas MIL-125(Ti)-NH<sub>2</sub> had 138.4&#xa0;mg/g (55.36%). The drug release kinetics follow Higuchi and Ritger-Peppas methods with a maximum release of 5-fluorouracil more than 92% for MIL-125(Ti)-NH<sub>2</sub> achieved within 48&#xa0;h and 88% for MIL-125(Ti). The optimum pH for 5-fluorouracil release is 5.5. The cytotoxicity of both MOFs to osteoblast cells indicates their non-toxic characteristics.</p>

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pH-responsive drug carriers MIL-125(Ti)-NH2 and MIL-125(Ti) for delivering colorectal cancer therapeutics 5-fluorouracil

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • Jindrayani Nyoo Putro,
  • Felycia Edi Soetaredjo,
  • Maria Yuliana,
  • Shella Permatasari Santoso,
  • Jenyfer Sugianto,
  • Kelvin Kelvin,
  • Christian Julius Wijaya,
  • I Gde Wenten,
  • Suryadi Ismadji

摘要

MIL-125(Ti) and its many modifications have demonstrated excellent biocompatibility, indicating significant potential as a drug carrier. This study examined the delivery potential of 5-fluorouracil using MIL-125(Ti) or MIL-125(Ti)-NH2. The synthesis of the two MOFs was conducted solvothermally at a temperature of 175 °C. This solvothermal approach yielded MOFs with distinct and clear diffraction peaks, indicating the high crystallinity of both resulting MOFs. Based on the nitrogen adsorption analysis, the surface areas for both MOFs were 712 m2/g for MIL-125(Ti) and 892 m2/g for MIL-125(Ti)-NH2. Both MOFs synthesized in this study possess micropore and small mesopore structures. In the 5-fluorouracil loading experiment, MIL-125(Ti) exhibited a maximum loading capacity of 118.7 mg/g (47.48%), whereas MIL-125(Ti)-NH2 had 138.4 mg/g (55.36%). The drug release kinetics follow Higuchi and Ritger-Peppas methods with a maximum release of 5-fluorouracil more than 92% for MIL-125(Ti)-NH2 achieved within 48 h and 88% for MIL-125(Ti). The optimum pH for 5-fluorouracil release is 5.5. The cytotoxicity of both MOFs to osteoblast cells indicates their non-toxic characteristics.