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<p>Therapeutically, repair and efficient healing of bone injuries are challenging and bone tissue engineering (BTE) is an emerging filed to resolve bone defects. It is performed without the typical complications associated with conventional autologous or allogeneic bone transplantation. A cost-effective bioactive polymeric nanocomposite was synthesised from nanocomposite (ZnO@GO) bacterial cellulose, carboxymethyl chitosan and acrylic acid by free radical polymerisation. Porous scaffolds were freeze-dried and the structure, surface morphology, elemental composition and mechanical properties were investigated by FTIR, XRD, SEM-EDX and UTM. Then, the physicochemical characteristics of scaffolds were determined by swelling in multiple media (Aqueous, PBS, and NaCl at 37&#xa0;°C) and degradation in PBS media (pH 7.4 at 37&#xa0;°C) to evaluate pH-responsive swelling and degradation of bioactive scaffolds. Antimicrobial and hemocompatibility investigations were carried out and these scaffolds exhibited excellent antibacterial activity and hemocompatibility. All scaffolds demonstrated significant biomineralization and promise for bone regeneration. The cytocompatibility was examined using preosteoblast (MC3T3-E1) cells by analysing cell viability, proliferation and morphology at different time periods. All scaffolds were evaluated for their structural, morphological, mechanical, and physicochemical properties, and BCGZ<sub>1.5</sub> was found to be the most suitable scaffold formulation. Thus, the results show that these scaffolds would be a potential material for repair and regeneration of defective bone by providing regulated, and desirable physicochemical and biomechanical characteristics.</p> Graphical Abstract <p></p>

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Synthesis of Bioactive Scaffold BC-co-CMCs-HAp Incorporated with ZnO@GO for Bone Tissue Engineering

  • 期刊论文

  • 发表日期：

    2026年6月18日

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  • Muhammad Umar Aslam Khan,
  • Talha Munir,
  • Saiqa Yousaf,
  • Abdalla Abdal-Hay,
  • Hassan Fouad,
  • Yichi Xu,
  • Mohamed Hashem

摘要

Therapeutically, repair and efficient healing of bone injuries are challenging and bone tissue engineering (BTE) is an emerging filed to resolve bone defects. It is performed without the typical complications associated with conventional autologous or allogeneic bone transplantation. A cost-effective bioactive polymeric nanocomposite was synthesised from nanocomposite (ZnO@GO) bacterial cellulose, carboxymethyl chitosan and acrylic acid by free radical polymerisation. Porous scaffolds were freeze-dried and the structure, surface morphology, elemental composition and mechanical properties were investigated by FTIR, XRD, SEM-EDX and UTM. Then, the physicochemical characteristics of scaffolds were determined by swelling in multiple media (Aqueous, PBS, and NaCl at 37 °C) and degradation in PBS media (pH 7.4 at 37 °C) to evaluate pH-responsive swelling and degradation of bioactive scaffolds. Antimicrobial and hemocompatibility investigations were carried out and these scaffolds exhibited excellent antibacterial activity and hemocompatibility. All scaffolds demonstrated significant biomineralization and promise for bone regeneration. The cytocompatibility was examined using preosteoblast (MC3T3-E1) cells by analysing cell viability, proliferation and morphology at different time periods. All scaffolds were evaluated for their structural, morphological, mechanical, and physicochemical properties, and BCGZ1.5 was found to be the most suitable scaffold formulation. Thus, the results show that these scaffolds would be a potential material for repair and regeneration of defective bone by providing regulated, and desirable physicochemical and biomechanical characteristics.

Graphical Abstract