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<p>Chronic and difficult-to-heal wounds are marked by excessive inflammation and oxidative stress, which hinder the normal healing process. Traditional wound dressings often lack the interactive therapeutic properties necessary to actively modify the adverse biochemical environment and facilitate regeneration. The primary objective of the current study was to develop an interactive nanofibrous wound dressing incorporating a β-cyclodextrin (β-CD)-rutin (Rut) inclusion complex. The solubility of Rutin was enhanced by including it in the cavity of β-CD, and the inclusion complex was characterized. The optimized β-CD/Rut inclusion complexes were loaded into polyvinyl alcohol (PVA)/polyvinylpyrrolidone (PVP) nanofibrous wound dressing using the electrospinning method. The modified nanofiber’s physicochemical properties (morphology, surface functional groups, weetablity, water vapour permeability, water absorption, and tensile strength) and biological activities (blood compatibility, biocompatibility, drug release, and antioxidant properties) were investigated. The simulation studies confirmed the inclusion of Rut into the cavity of β-CD and the formation of H-bonds between primary OH groups of β-CD and PVA. The total energies of β-CD, Rutin, PVA, PVP, and β-CD/Rut were obtained as -4273.008, -2233.550, -1538.672, -2951.199, and − 6522.447 Ha, respectively. The experimental studies indicated that β-CD/Rut inclusion complexes modified the biological activities of the nanofibrous wound dressing. The synthesized β-CD/Rut inclusion complexes exhibited dose-dependent antioxidant activities. The cell viability assay demonstrated that the fabricated nanofibrous wound dressing did not induce cytotoxicity and instead enhanced cell proliferation. These findings revealed that the complexation of Rut with β-CD can enhance the bioactivity of Rut, and the functionalized nanofibers can be applied as an interactive wound dressing.</p> Graphical Abstract <p></p>

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A Combined Experimental and Computational Analysis on Bioactive Nanofibrous Wound Dressing Based on β Cyclodextrin/Rutin Complex

  • 期刊论文

  • 发表日期：

    2026年4月6日

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  • Hadi Samadian,
  • Hamed Bashiri,
  • Zahra Hashemi,
  • Zhil Izadi,
  • Mohammad Hosein Farzaei,
  • Jafar Asadi,
  • Hossein Derakhshankhah

摘要

Chronic and difficult-to-heal wounds are marked by excessive inflammation and oxidative stress, which hinder the normal healing process. Traditional wound dressings often lack the interactive therapeutic properties necessary to actively modify the adverse biochemical environment and facilitate regeneration. The primary objective of the current study was to develop an interactive nanofibrous wound dressing incorporating a β-cyclodextrin (β-CD)-rutin (Rut) inclusion complex. The solubility of Rutin was enhanced by including it in the cavity of β-CD, and the inclusion complex was characterized. The optimized β-CD/Rut inclusion complexes were loaded into polyvinyl alcohol (PVA)/polyvinylpyrrolidone (PVP) nanofibrous wound dressing using the electrospinning method. The modified nanofiber’s physicochemical properties (morphology, surface functional groups, weetablity, water vapour permeability, water absorption, and tensile strength) and biological activities (blood compatibility, biocompatibility, drug release, and antioxidant properties) were investigated. The simulation studies confirmed the inclusion of Rut into the cavity of β-CD and the formation of H-bonds between primary OH groups of β-CD and PVA. The total energies of β-CD, Rutin, PVA, PVP, and β-CD/Rut were obtained as -4273.008, -2233.550, -1538.672, -2951.199, and − 6522.447 Ha, respectively. The experimental studies indicated that β-CD/Rut inclusion complexes modified the biological activities of the nanofibrous wound dressing. The synthesized β-CD/Rut inclusion complexes exhibited dose-dependent antioxidant activities. The cell viability assay demonstrated that the fabricated nanofibrous wound dressing did not induce cytotoxicity and instead enhanced cell proliferation. These findings revealed that the complexation of Rut with β-CD can enhance the bioactivity of Rut, and the functionalized nanofibers can be applied as an interactive wound dressing.

Graphical Abstract