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<p>An innovative solvent casting method was used to develop a series of biodegradable PCL/APTES-functionalized bioactive glass (F-BG) nanocomposites, with the goal of creating bone scaffolds that provide both robust mechanical support and a favorable biological environment. The study systematically evaluated composites with BG content ranging from 15% to 45%. Mechanical testing showed that the PCL/32% F-BG composite exhibited the highest flexural strength (25.8&#xa0;MPa), while the PCL/45% F-BG composite achieved the highest elastic modulus (1793&#xa0;MPa). This enhanced mechanical performance is crucial, as it allows the scaffold to more closely match the mechanical properties of adjacent bone tissue, a key factor for successful osteointegration. Microstructural analysis confirmed the uniform dispersion of the 56&#xa0;nm BG nanoparticles, which underpinned the superior properties. Furthermore, comprehensive biological evaluations) including hydrophilicity, controlled degradation, and cytocompatibility using NIH3T3 cells (demonstrated the composite’s excellent biological response. The biocompatibility of the nanocomposites was confirmed by the MTT assay, which showed a notable increase in cell viability from approximately 84% for neat PCL to over 92% for the optimal 32% F-BG composite.</p> Graphical Abstract <p></p>

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Optimized Fabrication and Enhanced Flexural Properties of PCL/F-BG Nanocomposites for Hard Tissue Engineering

  • 期刊论文

  • 发表日期：

    2025年11月4日

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  • Sanaz Toorani,
  • Majid Sohrabian,
  • Mahmood Sameezadeh,
  • Mohadeseh Khalafi

摘要

An innovative solvent casting method was used to develop a series of biodegradable PCL/APTES-functionalized bioactive glass (F-BG) nanocomposites, with the goal of creating bone scaffolds that provide both robust mechanical support and a favorable biological environment. The study systematically evaluated composites with BG content ranging from 15% to 45%. Mechanical testing showed that the PCL/32% F-BG composite exhibited the highest flexural strength (25.8 MPa), while the PCL/45% F-BG composite achieved the highest elastic modulus (1793 MPa). This enhanced mechanical performance is crucial, as it allows the scaffold to more closely match the mechanical properties of adjacent bone tissue, a key factor for successful osteointegration. Microstructural analysis confirmed the uniform dispersion of the 56 nm BG nanoparticles, which underpinned the superior properties. Furthermore, comprehensive biological evaluations) including hydrophilicity, controlled degradation, and cytocompatibility using NIH3T3 cells (demonstrated the composite’s excellent biological response. The biocompatibility of the nanocomposites was confirmed by the MTT assay, which showed a notable increase in cell viability from approximately 84% for neat PCL to over 92% for the optimal 32% F-BG composite.

Graphical Abstract