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<p>This research focuses on creating an innovative pH-sensitive nanocarrier for targeted paclitaxel delivery to breast cancer cells. The nanocarrier, consisting of hyaluronic acid grafted poly (acrylic acid-co-allyl glycidyl ether) conjugated mesoporous magnetic graphene quantum dots, is engineered to release the drug specifically in the acidic tumor environment. The study examined key factors affecting paclitaxel measurement. The Langmuir model provided the best fit, with a maximum sorption capacity of 15.851 mg g<sup>−1</sup>. Kinetic modeling aligned well with the pseudo-second order kinetic model, supporting physisorption in the adsorption process, facilitated by a high density of active sites. Thermodynamic analysis revealed that drug adsorption onto nanocomposite was endothermic and spontaneous. The drug-loaded nanocomposite exhibited limited release in simulated physiological conditions (pH 7.4, 37&#xa0;°C), but increased release in tumor tissue conditions (pH 5.6, 37&#xa0;°C), enabling sustained drug release at the target site. The zero-order kinetic model best described drug release from the nanocarrier at pH 5.6, indicating non-Fickian diffusion transport control. The cytotoxicity results demonstrated that the nanocarrier was more toxic to MCF-7 cells than nanocomposite without the drug. Based on the collected data, the developed nanocarrier with appropriate pH-responsiveness shows significant potential as an anticancer agent.</p>

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Hyaluronic Acid Conjugated Poly (Acrylic Acid-co-Allyl Glycidyl Ether) Grafted Mesoporous Magnetic Graphene Quantum Dots as a Novel pH-Responsive Nanocarrier for Targeted Drug Delivery of Paclitaxel To Breast Cancer Treatment

  • 期刊论文

  • 发表日期：

    2025年10月25日

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  • Ehsan Bilchi,
  • Hamidreza Shahbaazi,
  • Elham Moniri,
  • Mahsasadat Miralinaghi

摘要

This research focuses on creating an innovative pH-sensitive nanocarrier for targeted paclitaxel delivery to breast cancer cells. The nanocarrier, consisting of hyaluronic acid grafted poly (acrylic acid-co-allyl glycidyl ether) conjugated mesoporous magnetic graphene quantum dots, is engineered to release the drug specifically in the acidic tumor environment. The study examined key factors affecting paclitaxel measurement. The Langmuir model provided the best fit, with a maximum sorption capacity of 15.851 mg g−1. Kinetic modeling aligned well with the pseudo-second order kinetic model, supporting physisorption in the adsorption process, facilitated by a high density of active sites. Thermodynamic analysis revealed that drug adsorption onto nanocomposite was endothermic and spontaneous. The drug-loaded nanocomposite exhibited limited release in simulated physiological conditions (pH 7.4, 37 °C), but increased release in tumor tissue conditions (pH 5.6, 37 °C), enabling sustained drug release at the target site. The zero-order kinetic model best described drug release from the nanocarrier at pH 5.6, indicating non-Fickian diffusion transport control. The cytotoxicity results demonstrated that the nanocarrier was more toxic to MCF-7 cells than nanocomposite without the drug. Based on the collected data, the developed nanocarrier with appropriate pH-responsiveness shows significant potential as an anticancer agent.