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<p>The delivery of chemotherapeutic agents to bone tumors is a hindered by limited bone bioavailability and a dense extracellular matrix. Recent research has focused on targeted anticancer drug delivery to bone-tumor sites using various polymeric nanomicelles. In this study, hyaluronic acid-based polymeric nanomicelles, functionalized with the bone-targeting ligand sodium alendronate, were developed for the targeted treatment of metastatic bone cancers. The successful synthesis of polymer was confirmed using <sup>1</sup>HNMR and FTIR spectroscopy. The synthesized polymer exhibited a low critical micelle concentration (CMC) of 19.3&#xa0;µg/ml, indicating its robust ability to form and maintain stable nanomicelles in biological media. Dynamic light scattering (DLS) analysis revealed an average nanomicelle size of 129&#xa0;nm, and field-emission scanning electron microscopy (FESEM) confirmed their spherical morphology. Curcumin (CUR) was selected as the anticancer therapeutic compound and encapsulated within the hydrophobic core of the nanomicelles, achieving a high drug loading capacity of 9.8%. A sustained in vitro release profile of CUR was observed over 100&#xa0;h. The in vitro affinity of the nanomicelles for hydroxyapatite was determined to be 77.5%. Cytotoxicity and hemolysis assays demonstrated that the nanomicelles exhibited no significant toxicity towards fibroblast cells or red blood cells. The IC50 values, determined by MTT assay on MDA-MB-231 cell Lines after 24&#xa0;h of incubation, were 72.1&#xa0;µg/mL for the drug-loaded nanomicelles and 110.3&#xa0;µg/mL for free CUR. These findings suggest that these bone-targeted polymeric nanomicelles hold promise as a potential therapeutic strategy for bone cancer metastasis.</p>

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Bone-Targeted Hyaluronic Acid-based Polymeric Nanomicelles for Curcumin Delivery: Design, in Vitro Characterization and Cytotoxicity Evaluation

  • 期刊论文

  • 发表日期：

    2025年9月30日

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  • Mohammadmahdi Eshaghi,
  • Fariba Ganji,
  • Hossein Shaki

摘要

The delivery of chemotherapeutic agents to bone tumors is a hindered by limited bone bioavailability and a dense extracellular matrix. Recent research has focused on targeted anticancer drug delivery to bone-tumor sites using various polymeric nanomicelles. In this study, hyaluronic acid-based polymeric nanomicelles, functionalized with the bone-targeting ligand sodium alendronate, were developed for the targeted treatment of metastatic bone cancers. The successful synthesis of polymer was confirmed using 1HNMR and FTIR spectroscopy. The synthesized polymer exhibited a low critical micelle concentration (CMC) of 19.3 µg/ml, indicating its robust ability to form and maintain stable nanomicelles in biological media. Dynamic light scattering (DLS) analysis revealed an average nanomicelle size of 129 nm, and field-emission scanning electron microscopy (FESEM) confirmed their spherical morphology. Curcumin (CUR) was selected as the anticancer therapeutic compound and encapsulated within the hydrophobic core of the nanomicelles, achieving a high drug loading capacity of 9.8%. A sustained in vitro release profile of CUR was observed over 100 h. The in vitro affinity of the nanomicelles for hydroxyapatite was determined to be 77.5%. Cytotoxicity and hemolysis assays demonstrated that the nanomicelles exhibited no significant toxicity towards fibroblast cells or red blood cells. The IC50 values, determined by MTT assay on MDA-MB-231 cell Lines after 24 h of incubation, were 72.1 µg/mL for the drug-loaded nanomicelles and 110.3 µg/mL for free CUR. These findings suggest that these bone-targeted polymeric nanomicelles hold promise as a potential therapeutic strategy for bone cancer metastasis.