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<p>Pathogenic microbes pose a significant threat to human health due to their increasing resistance to standard antibiotics. Colon cancer is among the deadliest forms of cancer worldwide and often exhibits resistance to conventional treatments, highlighting the urgent need for alternative therapeutic agents. In this study, a SrO<sub>2</sub>–SA–LA nanocomposite was synthesized via a green chemical approach using <i>Bougainvillea glabra</i> extract and evaluated for its anticancer, antioxidant, and antimicrobial potential. In this work, SrO<sub>2</sub>-SA-LA nanocomposite was prepared via a green chemical approach using <i>Bougainvillea glabra</i> extract and evaluated for its potential anticancer, antioxidant, and antimicrobial properties. The nanocomposite was successfully synthesized and functionalized, as confirmed by characterization studies. XRD revealed a crystalline phase of tetragonal SrO<sub>2</sub>. The calculated optical bandgap energies were 4.11&#xa0;eV for pristine SrO<sub>2</sub> and 4.35&#xa0;eV for SrO<sub>2</sub>-SA-LA nanocomposite. DLS analysis indicated median particle sizes of 128.40&#xa0;nm and 142.70&#xa0;nm for SrO₂ and SrO<sub>2</sub>–SA–LA, respectively. PL studies showed that the SrO<sub>2</sub>–SA–LA nanocomposite exhibited green emission in the range of 494–534&#xa0;nm, suggesting an increase in oxygen-related defect states compared to pure SrO<sub>2</sub>. Disc diffusion assay revealed that SrO<sub>2</sub>-SA-LA nanocomposite exhibited enhanced antimicrobial activity against common disease-causing pathogens, while MTT assay showed enhanced cytotoxicity against HCT-116 colon cancer cells. Additionally, the SrO<sub>2</sub>-SA-LA nanocomposite exhibited superior free radical scavenging in DPPH assays, indicating high antioxidant potential. Furthermore, cytocompatibility studies using L929 fibroblast cells confirmed that both SrO₂ and SrO₂–SA–LA nanocomposite are non-toxic to normal cells, with cell viability exceeding 80%, indicating their biosafety. The results suggest that SrO<sub>2</sub>-SA-LA nanocomposite is a promising candidate for applications in anticancer, antioxidant, and antimicrobial therapies with good biocompatibility.</p>

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Multifunctional SrO₂–Sodium Alginate–L-Arginine Nanocomposite: A Green Approach against Colon Cancer and Pathogenic Microbes

  • 期刊论文

  • 发表日期：

    2025年8月4日

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  • G. PadmaPriya,
  • Anand Joshi,
  • Ankit Sachdeva,
  • Jagdish Kumar Arun,
  • AbdulAziz A. AlGhamdi,
  • Srinivas Tadepalli,
  • Indumathi Thangavelu

摘要

Pathogenic microbes pose a significant threat to human health due to their increasing resistance to standard antibiotics. Colon cancer is among the deadliest forms of cancer worldwide and often exhibits resistance to conventional treatments, highlighting the urgent need for alternative therapeutic agents. In this study, a SrO2–SA–LA nanocomposite was synthesized via a green chemical approach using Bougainvillea glabra extract and evaluated for its anticancer, antioxidant, and antimicrobial potential. In this work, SrO2-SA-LA nanocomposite was prepared via a green chemical approach using Bougainvillea glabra extract and evaluated for its potential anticancer, antioxidant, and antimicrobial properties. The nanocomposite was successfully synthesized and functionalized, as confirmed by characterization studies. XRD revealed a crystalline phase of tetragonal SrO2. The calculated optical bandgap energies were 4.11 eV for pristine SrO2 and 4.35 eV for SrO2-SA-LA nanocomposite. DLS analysis indicated median particle sizes of 128.40 nm and 142.70 nm for SrO₂ and SrO2–SA–LA, respectively. PL studies showed that the SrO2–SA–LA nanocomposite exhibited green emission in the range of 494–534 nm, suggesting an increase in oxygen-related defect states compared to pure SrO2. Disc diffusion assay revealed that SrO2-SA-LA nanocomposite exhibited enhanced antimicrobial activity against common disease-causing pathogens, while MTT assay showed enhanced cytotoxicity against HCT-116 colon cancer cells. Additionally, the SrO2-SA-LA nanocomposite exhibited superior free radical scavenging in DPPH assays, indicating high antioxidant potential. Furthermore, cytocompatibility studies using L929 fibroblast cells confirmed that both SrO₂ and SrO₂–SA–LA nanocomposite are non-toxic to normal cells, with cell viability exceeding 80%, indicating their biosafety. The results suggest that SrO2-SA-LA nanocomposite is a promising candidate for applications in anticancer, antioxidant, and antimicrobial therapies with good biocompatibility.