Innovative Nanocomposite Scaffolds Containing ZIF-8 Nanoparticles for Improving Wound Healing: A Review

Multifunctional nanocomposite scaffolds, particularly those incorporating zeolitic imidazolate framework-8 nanoparticles (ZIF-8 NPs), are emerging as effective solutions for skin and tissue injuries due to their biocompatibility, structural stability, and antibacterial properties. Integrating ZIF-8 NPs into polymeric scaffolds has significant potential for improved tissue regeneration. This review examines recent advancements in ZIF-8 NP-integrated scaffolds, including their applications in nanofibers, hydrogels, microneedles, and 3D-printable scaffolds. It details the synthesis methods, structural characteristics, and physicochemical properties of ZIF-8 NPs, highlighting their role in enhancing wound healing. The methodological basis of ZIF-8 in wound healing applications involves its synthesis and functionalization to enhance biocompatibility, enabling the creation of drug delivery systems that release bioactive agents in a controlled manner to promote tissue regeneration and accelerate wound healing. This review highlights the biocompatibility and biosafety of ZIF-8 NPs, noting their non-toxic nature within specific concentration ranges and their multifunctional capabilities, such as antibacterial and anti-inflammatory effects that facilitate angiogenesis and infection management. The review also addresses current challenges and future perspectives in developing and clinically translating ZIF-8-based nanocomposite scaffolds as next-generation materials for improving wound healing.