Green Decorated Au NPs Over Arabic Gum Functionalized Reduced Graphene Oxide for the In-Vitro Study of Lung Carcinoma and Antioxidant Potential Assay

The current research demonstrates the design, synthesis and development of a bio-inspired and green formulated nanomedicines to combat human lung cancer. The application of phytochemicals modified biocompatible nanocomposites have been an immense thrust towards biological investigations and medicinal therapeutics. In this regard, we have developed a sustainable nanomaterial having Au NPs immobilized over high surface carbonaceous support (reduced graphene oxide, RGO) bio-inspired by Arabic gum (RGO/AG/Au). The material has been meticulously characterized over FT-IR (Fourier Transformed Infra Red spectroscopy), FE-SEM (Field Emission Scanning Electron Microscopy), EDX (Energy Dispersive X ray spectroscopy), TEM (Transmission Electron Microscopy), XRD (X-ray Diffraction) and Thermo Gravimetric Analysis (TGA) techniques. Towards its bio-application, the antioxidant assay studied by DPPH radical scavenging process. IC₅₀ of this analysis was found as 80 µg/ml. The study was further extended in restricting the proliferation of human lung cancer cell lines, NCI-H661, NCI-H1975, NCI-H1573, and NCI-H1563 following MTT colorimetric method and the related IC₅₀ were determined as 118, 197, 175, and 69 µg/mL respectively. The excellent anti-cancer property exhibited by RGO/AG/Au was anticipated based on the good antioxidant potential of the material.