<p>The exoskeleton of cingulates is an essential structure for paleopathological analysis as it provides additional information on paleobiology beyond the endoskeleton. The carapaces and tails comprise a bony armor that covers the body and is susceptible to alterations caused by diseases of different etiologies, such as parasitic, infectious or traumatic. Through macroscopic examination and digital microscopy of the components of the exoskeleton, we have identified for the first time potential tungiasis cases in five genera of glyptodonts, <i>Plohophorus</i>, <i>Stromaphorus</i>,<i> Nopachtus</i>, <i>Neosclerocalyptus</i>, <i>Hoplophorus</i>, and additional cases for <i>Panochthus</i> and <i>Glyptodon</i>, as well as cutaneous diseases caused by opportunistic microorganisms across all these genera, which includes the first record of fungal lesions on the external surface of the exoskeleton of a glyptodont. The purported flea borings can vary in size and shape according to the ossification of the exoskeleton site; less ossified points tend to have deeper holes. Cutaneous pathologies are predominantly associated with flea infestation and trauma caused by fights becoming a secondary problem. The mapping of potential bone tungiasis in South American glyptodonts from recorded cases revealed that this disease was biogeographically widespread compared to today.</p>