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<p>Nanofiber (NF) integrated biomedical textiles have investigated as promising multifunctional platforms for creating smart healthcare applications, wound care, tissue engineering, controlled drug delivery, protective apparel, and hygiene goods. Nevertheless, current reviews frequently consider biological performance, fiber design, bioactive loading, polymer selection, and sustainability as distinct subjects, offering limited understanding of how functional agents are fixed, held, and released throughout usage. This study critically investigates recent advances in NF-based biomedical textiles particularly concentrating on material design linking with functionalization-fixation strategies with interfacial chemistry, functional performance and retention characteristics, environmental consequences, industrial scalability and applications. Predominant polymeric platforms including polyurethanes, aliphatic polyesters, protein-based biopolymers, cellulose derivatives, silk fibroin, chitosan, and polysaccharides, are discussed in relation to their biomedical role, benefits and drawbacks. The review further assesses fixation mechanisms for physical, chemical, interfacial, and structural methods that are employed, either separately or in combination, to immobilize bioactive compounds inside nanofiber matrices. The influence of different design methodologies on wound-healing response, drug retention, ion-release kinetics, reactive oxygen species generation, sustained antibacterial performance, durability, swelling, mechanical stability, biocompatibility, and bio-safety features is thoroughly explored. Critical analysis also revealed that ion-leaching, processing sustainability, dose-dependent toxicity, weak post-sterilization stability, variations in retention time in different reports, and limited washing, aging, and functional life-time assessment remain as the key translational challenges. This review offers a useful framework for developing next-generation biomedical textile technologies with improved clinical durability, industrial scalability, biocompatibility, and potential for sustainable application.</p> Graphical Abstract <p></p>

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Next-Generation Biomedical Nanofiber Textiles: Material Design, Fixation Strategies, Functional Performance, Environmental Implications and Challenges

  • 期刊论文

  • 发表日期：

    2026年7月28日

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  • Jabed Hossen Emon,
  • Md. Abdullah Al Jaman,
  • Hasibul Hasan,
  • Md. Sayful Islam

摘要

Nanofiber (NF) integrated biomedical textiles have investigated as promising multifunctional platforms for creating smart healthcare applications, wound care, tissue engineering, controlled drug delivery, protective apparel, and hygiene goods. Nevertheless, current reviews frequently consider biological performance, fiber design, bioactive loading, polymer selection, and sustainability as distinct subjects, offering limited understanding of how functional agents are fixed, held, and released throughout usage. This study critically investigates recent advances in NF-based biomedical textiles particularly concentrating on material design linking with functionalization-fixation strategies with interfacial chemistry, functional performance and retention characteristics, environmental consequences, industrial scalability and applications. Predominant polymeric platforms including polyurethanes, aliphatic polyesters, protein-based biopolymers, cellulose derivatives, silk fibroin, chitosan, and polysaccharides, are discussed in relation to their biomedical role, benefits and drawbacks. The review further assesses fixation mechanisms for physical, chemical, interfacial, and structural methods that are employed, either separately or in combination, to immobilize bioactive compounds inside nanofiber matrices. The influence of different design methodologies on wound-healing response, drug retention, ion-release kinetics, reactive oxygen species generation, sustained antibacterial performance, durability, swelling, mechanical stability, biocompatibility, and bio-safety features is thoroughly explored. Critical analysis also revealed that ion-leaching, processing sustainability, dose-dependent toxicity, weak post-sterilization stability, variations in retention time in different reports, and limited washing, aging, and functional life-time assessment remain as the key translational challenges. This review offers a useful framework for developing next-generation biomedical textile technologies with improved clinical durability, industrial scalability, biocompatibility, and potential for sustainable application.

Graphical Abstract