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<p>Hemodialysis membranes often suffer from limited biocompatibility and lack of antibacterial functionality, increasing the risk of infections in patients. In this study, polyethersulfone (PES) membranes were modified via in situ incorporation of silver nanoparticles (Ag-NPs) to improve both antimicrobial performance and blood compatibility. The developed membranes exhibited high filtration efficiency (BSA rejection &gt; 95% and creatinine clearance up to ~ 99%), enhanced hydrophilicity, and low silver release (≈1.5–3&#xa0;µg/cm<sup>2</sup>), while maintaining excellent hemocompatibility and no cytotoxicity. Additionally, Ag-NP-modified membranes demonstrated bacteriostatic activity against <i>P. aeruginosa</i> and <i>S. aureus</i>. The novelty of this work lies in achieving a balanced combination of filtration performance, antibacterial activity, and biocompatibility through stable in situ nanoparticle incorporation, highlighting their potential for advanced hemodialysis applications.</p>

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Silver Nanoparticle Enhanced Polyethersulfone Membranes for Potential Hemodialysis Application: Balancing Antibacterial Activity and Biocompatibility

  • 期刊论文

  • 发表日期：

    2026年6月18日

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  • Aleksandra Domke,
  • Ewa Sobkowiak,
  • Marcin Chodkowski,
  • Agnieszka Kauc,
  • Małgorzata Antos-Bielska,
  • Małgorzata Krzyżowska,
  • Zuzanna Buchwald,
  • Mariusz Jancelewicz,
  • Maria Ratajczak,
  • Piotr Gajewski,
  • Marta Woźniak-Budych,
  • Katarzyna Staszak

摘要

Hemodialysis membranes often suffer from limited biocompatibility and lack of antibacterial functionality, increasing the risk of infections in patients. In this study, polyethersulfone (PES) membranes were modified via in situ incorporation of silver nanoparticles (Ag-NPs) to improve both antimicrobial performance and blood compatibility. The developed membranes exhibited high filtration efficiency (BSA rejection > 95% and creatinine clearance up to ~ 99%), enhanced hydrophilicity, and low silver release (≈1.5–3 µg/cm2), while maintaining excellent hemocompatibility and no cytotoxicity. Additionally, Ag-NP-modified membranes demonstrated bacteriostatic activity against P. aeruginosa and S. aureus. The novelty of this work lies in achieving a balanced combination of filtration performance, antibacterial activity, and biocompatibility through stable in situ nanoparticle incorporation, highlighting their potential for advanced hemodialysis applications.