Scholarlink

<p>The electrochemical oxidation of the anticancer drug methotrexate (MTX) was investigated using a glassy carbon electrode modified with a NiFe<sub>2</sub>O<sub>4</sub>@g-C<sub>3</sub>N<sub>4</sub> nanocomposite. The modified electrode exhibited a clear and enhanced irreversible oxidation signal for MTX compared to the bare electrode. Cyclic and differential pulse voltammetry studies showed that the oxidation process was diffusion-controlled and influenced by scan rate and solution pH. Under optimized conditions, the sensor demonstrated high sensitivity and enabled the simultaneous detection of MTX and folic acid with well-resolved peaks. The modified electrode also displayed good stability, reproducibility, and selectivity, indicating its suitability for electrochemical determination of MTX in biological samples.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Bio-synthesis of NiFe2O4@g-C3N4 Nanocomposite for Simultaneous Detection of Anticancer Drug Methotrexate and Folic Acid in Biological Fluids

  • 期刊论文

  • 发表日期：

    2026年5月3日

查看全文
  • Mortaga M. Abou-Krisha,
  • Abdulrahman G. Alhamzani,
  • Mohamed Abd-Elsabour

摘要

The electrochemical oxidation of the anticancer drug methotrexate (MTX) was investigated using a glassy carbon electrode modified with a NiFe2O4@g-C3N4 nanocomposite. The modified electrode exhibited a clear and enhanced irreversible oxidation signal for MTX compared to the bare electrode. Cyclic and differential pulse voltammetry studies showed that the oxidation process was diffusion-controlled and influenced by scan rate and solution pH. Under optimized conditions, the sensor demonstrated high sensitivity and enabled the simultaneous detection of MTX and folic acid with well-resolved peaks. The modified electrode also displayed good stability, reproducibility, and selectivity, indicating its suitability for electrochemical determination of MTX in biological samples.