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<p>Confronting the global health threat of antibiotic resistance, this work investigated polymer-functionalized silver nanomaterials as a promising antibacterial strategy. Using reversible addition-fragmentation chain transfer (RAFT) polymerization, we synthesized pH-responsive block (PE<i>b</i>PD) and random (PE<i>r</i>PD) copolymers. Grafting these polymers onto silver nanoparticles yielded functional nanocomposites designated AgNPs@PE<i>b</i>PD and AgNPs@PE<i>r</i>PD. Systematic adjustment of the copolymer-to-silver molar ratio (0.08:1-0.50:1) demonstrated distinct antibacterial performance. AgNPs@PE<i>b</i>PD showed strong activity against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> at a lower ratio (0.33:1), while AgNPs@PE<i>r</i>PD required a higher ratio (0.41:1) for comparable efficacy. Under acidic conditions, the nanocomposites acquired a positive surface charge, strengthening electrostatic attraction to bacterial membranes and promoting aggregation and structural damage. In vivo evaluation using a rat infection model confirmed that AgNPs@PE<i>b</i>PD significantly promoted wound healing compared to AgNPs@PE<i>r</i>PD. Histological analysis revealed enhanced epithelial regeneration and granulation tissue formation. These findings highlight how copolymer architecture (block versus random) critically influences antibacterial efficacy, providing valuable insights for designing advanced antimicrobial nanomaterials.</p>

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Acidity Activated Block Versus Random Copolymer Functionalized Silver Nanocomposites for Enhanced Antibacterial Activity

  • 期刊论文

  • 发表日期：

    2026年2月25日

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  • Qian Wang,
  • Buhui Tao,
  • Chao Huang,
  • Guang Tian,
  • Yi Tang,
  • Rui Wen,
  • Qianqian Guo,
  • Tianyu Lan,
  • Honglei Guo

摘要

Confronting the global health threat of antibiotic resistance, this work investigated polymer-functionalized silver nanomaterials as a promising antibacterial strategy. Using reversible addition-fragmentation chain transfer (RAFT) polymerization, we synthesized pH-responsive block (PEbPD) and random (PErPD) copolymers. Grafting these polymers onto silver nanoparticles yielded functional nanocomposites designated AgNPs@PEbPD and AgNPs@PErPD. Systematic adjustment of the copolymer-to-silver molar ratio (0.08:1-0.50:1) demonstrated distinct antibacterial performance. AgNPs@PEbPD showed strong activity against Escherichia coli and Staphylococcus aureus at a lower ratio (0.33:1), while AgNPs@PErPD required a higher ratio (0.41:1) for comparable efficacy. Under acidic conditions, the nanocomposites acquired a positive surface charge, strengthening electrostatic attraction to bacterial membranes and promoting aggregation and structural damage. In vivo evaluation using a rat infection model confirmed that AgNPs@PEbPD significantly promoted wound healing compared to AgNPs@PErPD. Histological analysis revealed enhanced epithelial regeneration and granulation tissue formation. These findings highlight how copolymer architecture (block versus random) critically influences antibacterial efficacy, providing valuable insights for designing advanced antimicrobial nanomaterials.