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<p>We study the effect of gold nanoparticles (Au-NPs) incorporation to structural, optical, and antioxidant properties as well as electronic structure of hydroxyapatite (HA). No structural change is observed upon doping, indicating the successful integration of Au-NPs into the HA matrix. Remarkably, a blue-shifted localized surface plasmon resonance (LSPR) occurs at 345&#xa0;nm accompanied with a reduction of band gap in HA upon Au-NPs doping, enhancing its light responsiveness in UV-visible range. The IC<sub>50</sub> value of HA in 2,2-diphenyl-1-picrylhydrazyl assay decreases from 105.01 ppm to 72.95 ppm as Au-NPs content increases, indicating the improved antioxidant activity due to the combined effects of blue-shifted LSPR, reduction of band gap, and catalytic properties of Au-NPs. Supported with theoretical calculations, we reveal that the emergence of blue-shifted LSPR and the reduction of band gap in Au-NPs-doped HA are attributed to hybridization of O 2<i>p</i> orbital with Au 5<i>d</i> and 6<i>s</i> orbitals due to strong electronic correlations. Our results highlight the potential of Au-NPs-doped HA as a multifunctional material for biomedical applications, paving the way toward advanced therapeutic technology.</p>

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Blue-Shifted Localized Surface Plasmon Resonance in Hydroxyapatite Doped with Gold Nanoparticles for Antioxidant Application

  • 期刊论文

  • 发表日期：

    2026年2月24日

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  • Angga Dito Fauzi,
  • Widatul Millah Nur Afifa,
  • Henny Putrie Meyyanti,
  • Dyah Hikmawati,
  • Ersyzario Edo Yunata,
  • Nuril Ukhrowiyah,
  • A. Suvitha

摘要

We study the effect of gold nanoparticles (Au-NPs) incorporation to structural, optical, and antioxidant properties as well as electronic structure of hydroxyapatite (HA). No structural change is observed upon doping, indicating the successful integration of Au-NPs into the HA matrix. Remarkably, a blue-shifted localized surface plasmon resonance (LSPR) occurs at 345 nm accompanied with a reduction of band gap in HA upon Au-NPs doping, enhancing its light responsiveness in UV-visible range. The IC50 value of HA in 2,2-diphenyl-1-picrylhydrazyl assay decreases from 105.01 ppm to 72.95 ppm as Au-NPs content increases, indicating the improved antioxidant activity due to the combined effects of blue-shifted LSPR, reduction of band gap, and catalytic properties of Au-NPs. Supported with theoretical calculations, we reveal that the emergence of blue-shifted LSPR and the reduction of band gap in Au-NPs-doped HA are attributed to hybridization of O 2p orbital with Au 5d and 6s orbitals due to strong electronic correlations. Our results highlight the potential of Au-NPs-doped HA as a multifunctional material for biomedical applications, paving the way toward advanced therapeutic technology.