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<p>This study reports the novel fabrication and comprehensive characterization of electrospun nanofibers mats based on polyvinyl alcohol (PVA) enhanced with bioactive chitosan and natural honey. Electrospinning was performed using PVA (PVA7), PVA-chitosan (PVA7C8) and PVA-Chitosan-Honey (PVA7C8H5) solutions. This work explores the synergetic integration of chitosan and honey into an electrospun nanofiber system, which has not been widely reported, especially with a focus on maintaining fiber morphology and optimizing antibacterial efficacy. Rheological analysis of the PVA based spinning solutions demonstrated Newtonian behaviour across all formulations, with viscosity reductions observed upon the incorporation of chitosan and honey-facilitating enhanced electrospinnability. ATR-FTIR spectroscopy revealed intermolecular hydrogen bonding interactions between the three components, suggesting successful molecular level integration. X-ray diffraction analysis confirmed the amorphous morphology of all nanofibers. Thermal stability (DSC-TGA) of the composites was retained up to ~ 200&#xa0;°C, with major degradation occurring between 250&#xa0;°C and 450&#xa0;°C. Morphological analysis (SEM and FE-SEM) verified the formation of smooth, bead-free nanofibers. Importantly, antibacterial testing towards <i>E.coli</i> using the well diffusion method demonstrated a significant zone of inhibition (1.30&#xa0;cm) for the PVA7C8H5 composite, highlighting the enhanced antimicrobial performance resulting from the dual bioactivity of chitosan and honey. This study presents an innovative biomaterial, which synergistically combines the robustness of synthetic polymers with the bioactivity of natural agents, resulting in a multifunctional nanofibrous dressing with superior antibacterial performance for wound healing.</p>

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Development and Characterization of Electrospun PVA-Chitosan-Honey Nanofiber Mats for Enhanced Antibacterial Performance

  • 期刊论文

  • 发表日期：

    2025年11月8日

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  • T. Radhika,
  • K. G. Vasanthakumari,
  • K. Sreelakshmi

摘要

This study reports the novel fabrication and comprehensive characterization of electrospun nanofibers mats based on polyvinyl alcohol (PVA) enhanced with bioactive chitosan and natural honey. Electrospinning was performed using PVA (PVA7), PVA-chitosan (PVA7C8) and PVA-Chitosan-Honey (PVA7C8H5) solutions. This work explores the synergetic integration of chitosan and honey into an electrospun nanofiber system, which has not been widely reported, especially with a focus on maintaining fiber morphology and optimizing antibacterial efficacy. Rheological analysis of the PVA based spinning solutions demonstrated Newtonian behaviour across all formulations, with viscosity reductions observed upon the incorporation of chitosan and honey-facilitating enhanced electrospinnability. ATR-FTIR spectroscopy revealed intermolecular hydrogen bonding interactions between the three components, suggesting successful molecular level integration. X-ray diffraction analysis confirmed the amorphous morphology of all nanofibers. Thermal stability (DSC-TGA) of the composites was retained up to ~ 200 °C, with major degradation occurring between 250 °C and 450 °C. Morphological analysis (SEM and FE-SEM) verified the formation of smooth, bead-free nanofibers. Importantly, antibacterial testing towards E.coli using the well diffusion method demonstrated a significant zone of inhibition (1.30 cm) for the PVA7C8H5 composite, highlighting the enhanced antimicrobial performance resulting from the dual bioactivity of chitosan and honey. This study presents an innovative biomaterial, which synergistically combines the robustness of synthetic polymers with the bioactivity of natural agents, resulting in a multifunctional nanofibrous dressing with superior antibacterial performance for wound healing.