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<p>Esomeprazole (ESO), a proton pump inhibitor, is used to manage gastroesophageal reflux disease (GERD), prevent nonsteroidal anti-inflammatory drugs (NSAIDs)- induced gastric ulcers, aid in <i>Helicobacter Pylori</i> eradication, and treat hypersecretory acid conditions. The present investigation introduces an innovative electrochemical sensing strategy for detecting ESO using a screen-printed electrode (SPE) modified with a newly synthesized zinc ferrite/polythiophene (ZnFe<sub>2</sub>O<sub>4</sub>/PTh) nanocomposite. The ZnFe<sub>2</sub>O<sub>4</sub> nanoparticles (NPs) were prepared using the sol-gel auto combustion method, while ZnFe<sub>2</sub>O<sub>4</sub>/PTh nanocomposites were synthesized through in situ chemical oxidative polymerization. The ZnFe<sub>2</sub>O<sub>4</sub> NPs display a cubic spinel crystalline structure and possess a rough surface morphology, with particle sizes less than 50&#xa0;nm. An efficient electrochemical sensing platform based on a ZnFe<sub>2</sub>O<sub>4</sub>/PTh/SPE was successfully developed for the selective determination of ESO. The electron-transfer characteristics of the fabricated electrode were investigated using cyclic voltammetry (CV), confirming its enhanced electrocatalytic activity. The proposed electrochemical method enabled sensitive quantification of ESO over a wide linear concentration range of 0.1–150 µM (R<sup>2</sup> = 0.996), with an excellent limit of detection (LOD) of 0.071 µM. The developed sensor was effectively utilized for the quantification of ESO in both pharmaceutical and biological matrices, with quantitative recovery values ranging from 94.6 to 101%.</p>

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Smart ZnFe2O4/Polythiophene Hybrid Interface for Rapid Esomeprazole Sensing

  • 期刊论文

  • 发表日期：

    2025年11月12日

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  • Shakoor Ahmed Solangi,
  • Faisal K. Algethami,
  • Jameel Ahmed Baig,
  • Imam Bakhsh Solangi,
  • Hassan Imran Afridi,
  • Fatehy M. Abdel-Haleem,
  • Latif Ullah Khan,
  • Sajjad Hussain

摘要

Esomeprazole (ESO), a proton pump inhibitor, is used to manage gastroesophageal reflux disease (GERD), prevent nonsteroidal anti-inflammatory drugs (NSAIDs)- induced gastric ulcers, aid in Helicobacter Pylori eradication, and treat hypersecretory acid conditions. The present investigation introduces an innovative electrochemical sensing strategy for detecting ESO using a screen-printed electrode (SPE) modified with a newly synthesized zinc ferrite/polythiophene (ZnFe2O4/PTh) nanocomposite. The ZnFe2O4 nanoparticles (NPs) were prepared using the sol-gel auto combustion method, while ZnFe2O4/PTh nanocomposites were synthesized through in situ chemical oxidative polymerization. The ZnFe2O4 NPs display a cubic spinel crystalline structure and possess a rough surface morphology, with particle sizes less than 50 nm. An efficient electrochemical sensing platform based on a ZnFe2O4/PTh/SPE was successfully developed for the selective determination of ESO. The electron-transfer characteristics of the fabricated electrode were investigated using cyclic voltammetry (CV), confirming its enhanced electrocatalytic activity. The proposed electrochemical method enabled sensitive quantification of ESO over a wide linear concentration range of 0.1–150 µM (R2 = 0.996), with an excellent limit of detection (LOD) of 0.071 µM. The developed sensor was effectively utilized for the quantification of ESO in both pharmaceutical and biological matrices, with quantitative recovery values ranging from 94.6 to 101%.