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<p>Mesoporous silica nanoparticles (MSNPs) are versatile drug carriers due to their excellent biocompatibility and large surface area; however, they carry the risk of premature drug release. The promising approach to overcome this challenge and enhance therapeutic efficacy relies on incorporating stimuli-responsive moieties on the surfaces of MSNPs. Herein, we present a method for synthesizing a heterocyclic Schiff base Cu(II) complex grafted onto MSNPs (Cu-L-MSNPs). Curcumin is then loaded onto Cu-L-MSNPs to produce a hybrid material, Cu-L-MSNPs/Cur. The Cu-L-MSNPs are studied for their drug encapsulation properties and in vitro pH-responsive drug release. The drug’s release percentage is 83.3% at pH 5.0 (tumour environment) and ~ 30% at pH 7.4 (extracellular environment of normal cells) after 72&#xa0;h. Furthermore, the Cu-L-MSNPs/Cur and Cu-L-MSNPs complexes are evaluated for their DPPH radical scavenging to check their antioxidant activities. The IC<sub>50</sub> values of Cu-L-MSNPs and Cu-L-MSNPs/Cur were found to be 37.94 and 33.84&#xa0;μg/mL, respectively. Moreover, the ability of Cu-L-MSNPs to immobilize the α-amylase enzyme is assessed through a starch hydrolysis assay. All the above results indicate that Cu-L-MSNPs are an effective motif for curcumin encapsulation and the entrapment of the α-amylase enzyme. The intriguing redox behaviour of transition metal complexes combined with Schiff base ligands (L) offers promising opportunities for developing dual-purpose carrier systems based on mesoporous silica, each leveraging inimitable properties.</p>

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A pH-Responsive Cu(II)-Coordinated Mesoporous Silica Nanoparticle-Based Drug Delivery System for Cervical Cancer Therapy and Immobilization of α-Amylase Enzyme

  • 期刊论文

  • 发表日期：

    2025年10月25日

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  • Bini Babu Sujatha,
  • Sindhu Yesodharan,
  • Thayyath Sreenivasan Anirudhan,
  • Selwin Joseyphus Raphael

摘要

Mesoporous silica nanoparticles (MSNPs) are versatile drug carriers due to their excellent biocompatibility and large surface area; however, they carry the risk of premature drug release. The promising approach to overcome this challenge and enhance therapeutic efficacy relies on incorporating stimuli-responsive moieties on the surfaces of MSNPs. Herein, we present a method for synthesizing a heterocyclic Schiff base Cu(II) complex grafted onto MSNPs (Cu-L-MSNPs). Curcumin is then loaded onto Cu-L-MSNPs to produce a hybrid material, Cu-L-MSNPs/Cur. The Cu-L-MSNPs are studied for their drug encapsulation properties and in vitro pH-responsive drug release. The drug’s release percentage is 83.3% at pH 5.0 (tumour environment) and ~ 30% at pH 7.4 (extracellular environment of normal cells) after 72 h. Furthermore, the Cu-L-MSNPs/Cur and Cu-L-MSNPs complexes are evaluated for their DPPH radical scavenging to check their antioxidant activities. The IC50 values of Cu-L-MSNPs and Cu-L-MSNPs/Cur were found to be 37.94 and 33.84 μg/mL, respectively. Moreover, the ability of Cu-L-MSNPs to immobilize the α-amylase enzyme is assessed through a starch hydrolysis assay. All the above results indicate that Cu-L-MSNPs are an effective motif for curcumin encapsulation and the entrapment of the α-amylase enzyme. The intriguing redox behaviour of transition metal complexes combined with Schiff base ligands (L) offers promising opportunities for developing dual-purpose carrier systems based on mesoporous silica, each leveraging inimitable properties.