<p>The novel adsorbent poly(3,4-ethylenedioxythiophene)/magnetite@zinc ferrite (PEDOT/Fe₃O₄@ZnFe₂O₄) was synthesized via chemical oxidation polymerization using oxaline, a deep eutectic solvent, for the adsorption of metronidazole (MET) and tetracycline (TC) from aqueous solution. A variety of methods, including FTIR, XRD, SEM, EDX, VSM, BET, and zeta potential techniques, were used to thoroughly characterize the synthesized adsorbent. Furthermore, adsorption studies were performed to investigate the effects of MET and TC concentration, pH, contact time, and adsorbent dosage. The optimal results show a removal efficiency of approximately 98.2% for MET and 94.3% for TC under the following conditions: pH 6 for MET and pH 5 for TC, utilizing 80&#xa0;mg of adsorbent, a drug concentration of 100&#xa0;mg/L, and stirring durations of 150&#xa0;min for MET and 180&#xa0;min for TC. The kinetic and isothermal models were used to thoroughly study the adsorption process. A pseudo-second-order kinetic model and Langmuir models were found to represent the best fits to the adsorption of MET and TC at 298&#xa0;K. Furthermore, the data showed that the PEDOT/Fe₃O₄@ZnFe₂O₄ nanocomposite had a high adsorption capacity of 122.73&#xa0;mg/g for TC and 137.15&#xa0;mg/g for MET. Thermodynamic findings demonstrated that the adsorption process was a spontaneous and endothermic reaction. The adsorbent demonstrated remarkable regenerative capabilities, enabling reuse for up to five cycles. Additionally, the study examined the adsorption of MET and TC pharmaceuticals from actual tablet samples using the PEDOT/Fe₃O₄@ZnFe₂O₄ nanocomposite. These findings highlight the potential of PEDOT/Fe₃O₄@ZnFe₂O₄ as an absorbent in the effective extraction of MET and TC from water sources.</p> Graphical Abstract <p></p>