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Abstract <p>In this study, a calcium-based metal‒organic framework (Ca-MOF) was synthesized using trimesic acid and glutaric acid as organic linkers for sensitive and selective antibiotic detection. The synthesized MOF was characterized via a variety of analytical techniques, such as FT-IR, PXRD, FESEM, EDX, XPS, TGA, BET, and HRTEM analyses. The crystalline nature of Ca-MOF was confirmed by powder XRD, whereas morphological investigations were performed via HRTEM and FESEM. The synthesized Ca-MOF demonstrated excellent fluorescence quenching or turn-off activity against different antibiotics, including ciprofloxacin, amoxicillin, doxycycline, sulfadiazine and tetracycline hydrochloride. Ca-MOF showed highest quenching efficiency against tetracycline hydrochloride while lowest limit of detection for amoxicillin antibiotics. The synthesized Ca-MOF showed remarkable sensitivity even for trace-level detection over 1.0–0.01&#xa0;µM concentration range, as demonstrated by the limits of detection (LODs). The Ca-MOFs show great potential as turn-off fluorescent sensors for the detection of antibiotics in environmental samples.</p> Graphical Abstract <p></p>

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Calcium-Based Metal–Organic Metal‒Organic Framework as a Turn-Off Fluorescent Sensor for Antibiotic Detection

  • 期刊论文

  • 发表日期：

    2025年9月27日

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  • Tanvi Verma,
  • Archana Thakur

摘要

Abstract

In this study, a calcium-based metal‒organic framework (Ca-MOF) was synthesized using trimesic acid and glutaric acid as organic linkers for sensitive and selective antibiotic detection. The synthesized MOF was characterized via a variety of analytical techniques, such as FT-IR, PXRD, FESEM, EDX, XPS, TGA, BET, and HRTEM analyses. The crystalline nature of Ca-MOF was confirmed by powder XRD, whereas morphological investigations were performed via HRTEM and FESEM. The synthesized Ca-MOF demonstrated excellent fluorescence quenching or turn-off activity against different antibiotics, including ciprofloxacin, amoxicillin, doxycycline, sulfadiazine and tetracycline hydrochloride. Ca-MOF showed highest quenching efficiency against tetracycline hydrochloride while lowest limit of detection for amoxicillin antibiotics. The synthesized Ca-MOF showed remarkable sensitivity even for trace-level detection over 1.0–0.01 µM concentration range, as demonstrated by the limits of detection (LODs). The Ca-MOFs show great potential as turn-off fluorescent sensors for the detection of antibiotics in environmental samples.

Graphical Abstract