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<p>Amoxicillin, a beta-lactam antibiotic, is used to treat bacterial infections. The rapid development of antibiotic resistance due to excessive and unmonitored global antibiotic use necessitates early detection of resistance to regulate antibiotic use and minimize side effects. In this context, the ternary nanocomposite (MnS-G-SiO<sub>2</sub>) synthesized onto a nickel foam electrode enables the detection of low concentration (0.05 µM) of amoxicillin with high electrical sensitivity. This nanocomposite was analyzed using powdered X-ray diffraction (XRD), Raman spectroscopy, XPS, DRS, Photocurrent, SEM, TEM, Cyclic voltammetry (CV), and various electrochemical experiments. The active materials, manganese sulfide (MnS) and silicon oxide (SiO<sub>2</sub>), provide enhanced electrochemical performance, biocompatibility, chemical stability, and catalytic properties. Additionally, graphene offers a high surface area, good conductivity, and rapid electron transfer. Nickel foam provides a large electroactive surface area, high intrinsic conductivity that enables fast electron transfer with cost- effective. The enzyme- free biosensor exhibited a good selectivity range (0.05–0.35 µM) with the detection of limit 0.85 µM in PBS. Furthermore, the sensor represents good stability, reproducibility and identity in different surroundings. Together, these properties make the nanocomposite an ideal biosensor for detecting low-concentration amoxicillin with high sensitivity.</p>

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Comparative Electrochemical Biosensor with Cost Effective Graphene-Based Metal Oxide Nanocomposites for Various Pharmaceutical Antibiotics and Biomedicines

  • 期刊论文

  • 发表日期：

    2025年7月28日

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  • Latiful Kabir,
  • Zuhong Ji,
  • Won-Chun Oh

摘要

Amoxicillin, a beta-lactam antibiotic, is used to treat bacterial infections. The rapid development of antibiotic resistance due to excessive and unmonitored global antibiotic use necessitates early detection of resistance to regulate antibiotic use and minimize side effects. In this context, the ternary nanocomposite (MnS-G-SiO2) synthesized onto a nickel foam electrode enables the detection of low concentration (0.05 µM) of amoxicillin with high electrical sensitivity. This nanocomposite was analyzed using powdered X-ray diffraction (XRD), Raman spectroscopy, XPS, DRS, Photocurrent, SEM, TEM, Cyclic voltammetry (CV), and various electrochemical experiments. The active materials, manganese sulfide (MnS) and silicon oxide (SiO2), provide enhanced electrochemical performance, biocompatibility, chemical stability, and catalytic properties. Additionally, graphene offers a high surface area, good conductivity, and rapid electron transfer. Nickel foam provides a large electroactive surface area, high intrinsic conductivity that enables fast electron transfer with cost- effective. The enzyme- free biosensor exhibited a good selectivity range (0.05–0.35 µM) with the detection of limit 0.85 µM in PBS. Furthermore, the sensor represents good stability, reproducibility and identity in different surroundings. Together, these properties make the nanocomposite an ideal biosensor for detecting low-concentration amoxicillin with high sensitivity.