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<p>The primary objective of this study was to develop a linezolid-loaded antibacterial active strontium mineral-substituted HAP (mHAP) composite that exhibited potent antibacterial activity against Staphylococcus aureus and MRSA. In this regard, strontium (Sr)-substituted hydroxyapatite (mHAP)-reinforced polymeric composites with linezolid (LNZ) were utilized. The brittle nature of the mHAP ceramic was overcome by adding with polymers such as polyvinyl pyrrolidone (PVP) and poly(sodium 4-styrene sulfonate) (PSSS). The composite formation, crystallinity, surface morphology, and zeta potential were investigated by Fourier Transform Infrared (FTIR), x-ray diffraction (XRD), scanning electron microscopy with Energy dispersive X-ray spectroscopy (SEM-EDX), high resolution–transmission electron microscopy (HR-TEM), and Zeta potential and particle size analysis techniques. The particle size and zeta potential were noted, and the zeta potential values of mHAP/PVP-PSSS and mHAP/PVP-PSSS/LNZ composites were found to be − 14.8 mV and − 40.3 mV, respectively. The bioactive results with SBF favored apatite formation and confirmed the composite’s biocompatibility with new bone formation. The cell viability of human bone marrow mesenchymal stem cells (hBMSCs) and the gene expression analysis confirmed the osteogenic potential of the prepared materials. Because the prepared composite offered promising results, these studies confirm that it exhibited sustained release of linezolid (77.8% over 24 days), supporting its potential for long-term infection control in osteomyelitis treatment and have potential clinical application.</p>

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Linezolid-Loaded Strontium-Substituted Hydroxyapatite-Biopolymeric Composite for Enhanced Bone Regeneration in Osteomyelitis Treatment

  • 期刊论文

  • 发表日期：

    2025年7月16日

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  • Hua Li,
  • Qi Du,
  • Pei-Yu Guo,
  • Yong-Tao Yi,
  • Suresh Mickymaray,
  • Anbarasan Balu,
  • Kaviya Suresh,
  • Xi Li

摘要

The primary objective of this study was to develop a linezolid-loaded antibacterial active strontium mineral-substituted HAP (mHAP) composite that exhibited potent antibacterial activity against Staphylococcus aureus and MRSA. In this regard, strontium (Sr)-substituted hydroxyapatite (mHAP)-reinforced polymeric composites with linezolid (LNZ) were utilized. The brittle nature of the mHAP ceramic was overcome by adding with polymers such as polyvinyl pyrrolidone (PVP) and poly(sodium 4-styrene sulfonate) (PSSS). The composite formation, crystallinity, surface morphology, and zeta potential were investigated by Fourier Transform Infrared (FTIR), x-ray diffraction (XRD), scanning electron microscopy with Energy dispersive X-ray spectroscopy (SEM-EDX), high resolution–transmission electron microscopy (HR-TEM), and Zeta potential and particle size analysis techniques. The particle size and zeta potential were noted, and the zeta potential values of mHAP/PVP-PSSS and mHAP/PVP-PSSS/LNZ composites were found to be − 14.8 mV and − 40.3 mV, respectively. The bioactive results with SBF favored apatite formation and confirmed the composite’s biocompatibility with new bone formation. The cell viability of human bone marrow mesenchymal stem cells (hBMSCs) and the gene expression analysis confirmed the osteogenic potential of the prepared materials. Because the prepared composite offered promising results, these studies confirm that it exhibited sustained release of linezolid (77.8% over 24 days), supporting its potential for long-term infection control in osteomyelitis treatment and have potential clinical application.