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<p>Nanotechnology-based strategies provide a promising platform for developing multifunctional materials with enhanced antibacterial, antioxidant, and anticancer properties, offering effective solutions for combating infections, oxidative stress, and osteosarcoma cell proliferation. In the current study BaO<sub>2</sub>-sodium alginate-curcumin (BaO₂-SA-Cur) was prepared by facile wet chemical route. The structural and morphological characteristics of the composite were ascertained using extensive characterization techniques. The crystallite size was found to be 52.2&#xa0;nm for BaO<sub>2</sub> and 43.1&#xa0;nm for BaO<sub>2</sub>-SA-Cur nanocomposite as per XRD analysis. UV-visible spectroscopy results revealed that the band gap was found as 4.54&#xa0;eV for BaO<sub>2</sub>-SA-Cur nanocomposite and 4.38&#xa0;eV for BaO<sub>2</sub> nanoparticles. PL studies revealed that the BaO<sub>2</sub>-SA-Cur nanocomposite exhibited intense emission peaks at 379&#xa0;nm, 421&#xa0;nm, 448&#xa0;nm, 477&#xa0;nm, and 508&#xa0;nm. DLS analysis revealed that the pure BaO<sub>2</sub> exhibited the particle size around 118.70 ± 5.4&#xa0;nm while the BaO₂-SA-Cur nanocomposite around 139.50 ± 7.8&#xa0;nm and more dispersion in the solution. The BaO₂-SA-Cur nanocomposite exhibited enhanced antibacterial action against multi-resistant gram-negative bacterial species (<i>Klebsiella pneumoniae</i>, <i>Escherichia coli</i>, <i>Shigella dysenteriae</i>, <i>Proteus vulgaris</i>, and <i>Pseudomonas aeruginosa</i>) than that of pure BaO₂ and comparable with streptomycin. Importantly, the nanocomposite revealed remarkable anticancer activity against the osteosarcoma MG-63 cells where Cur was synergistically inducing cell apoptosis. The IC<sub>50</sub> value was calculated as 45.7 for undoped BaO<sub>2</sub> and 35.6 for doped BaO<sub>2</sub>-SA-Cur composite. Biocompatibility studies on L929 fibroblast cells showed over 85% cell viability for BaO₂-SA-Cur, confirming its low cytotoxicity and suitability for biomedical applications.</p>

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Synthesis and Multifunctional Evaluation of BaO₂-Sodium Alginate-Curcumin Nanocomposite: Improved Antibacterial, Antioxidant, and Osteosarcoma Cell Inhibition

  • 期刊论文

  • 发表日期：

    2025年7月12日

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  • Vijay Bhalla,
  • Chandra Prabha Sahu,
  • A. R. Shashikala,
  • Sulochana Singh,
  • Indumathi Thangavelu,
  • Srinivas Tadepalli,
  • Ahmed A. Bhran

摘要

Nanotechnology-based strategies provide a promising platform for developing multifunctional materials with enhanced antibacterial, antioxidant, and anticancer properties, offering effective solutions for combating infections, oxidative stress, and osteosarcoma cell proliferation. In the current study BaO2-sodium alginate-curcumin (BaO₂-SA-Cur) was prepared by facile wet chemical route. The structural and morphological characteristics of the composite were ascertained using extensive characterization techniques. The crystallite size was found to be 52.2 nm for BaO2 and 43.1 nm for BaO2-SA-Cur nanocomposite as per XRD analysis. UV-visible spectroscopy results revealed that the band gap was found as 4.54 eV for BaO2-SA-Cur nanocomposite and 4.38 eV for BaO2 nanoparticles. PL studies revealed that the BaO2-SA-Cur nanocomposite exhibited intense emission peaks at 379 nm, 421 nm, 448 nm, 477 nm, and 508 nm. DLS analysis revealed that the pure BaO2 exhibited the particle size around 118.70 ± 5.4 nm while the BaO₂-SA-Cur nanocomposite around 139.50 ± 7.8 nm and more dispersion in the solution. The BaO₂-SA-Cur nanocomposite exhibited enhanced antibacterial action against multi-resistant gram-negative bacterial species (Klebsiella pneumoniae, Escherichia coli, Shigella dysenteriae, Proteus vulgaris, and Pseudomonas aeruginosa) than that of pure BaO₂ and comparable with streptomycin. Importantly, the nanocomposite revealed remarkable anticancer activity against the osteosarcoma MG-63 cells where Cur was synergistically inducing cell apoptosis. The IC50 value was calculated as 45.7 for undoped BaO2 and 35.6 for doped BaO2-SA-Cur composite. Biocompatibility studies on L929 fibroblast cells showed over 85% cell viability for BaO₂-SA-Cur, confirming its low cytotoxicity and suitability for biomedical applications.