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<p>In response to the urgent need for safer and more effective antimicrobial and anticancer agents, this study aims to develop and evaluate biocompatible nanoparticles synthesized using green method, with enhanced therapeutic efficacy over conventional treatments. The present work focuses on synthesizing <i>Azadirachta indica</i> leaf extract-mediated zinc oxide (ZnO) and chitosan L-tartaric acid doped zinc oxide (ZnCsLT) NPs for its antibacterial, antifungal, and anticancer activity. XRD, DLS, FTIR, FESEM, EDAX, UV-Vis, PL, and XPS are the analytical techniqes used to characterize the synthesized ZnO and ZnCsLT NPs. The synthesized NPs exhibit wurtzite hexagonal structures, as confirmed by XRD studies. Nanoflake and spherical polyhedron structures were observed through HR-TEM and FESEM analysis. The elemental composition of the synthesized nanoparticles was confirmed through EDAX analysis. Antibacterial evaluation at a concentration of 2&#xa0;µg/mL revealed that ZnCsLT nanoparticles exhibited superior activity compared to unmodified ZnO nanoparticles, with inhibition zones ranging between 14 and 16&#xa0;mm against various bacterial strains. In vitro assessments of anticancer and cytotoxic effects were conducted using MDA-MB-237 human breast cancer cells and L929 fibroblast cells. The ZnCsLT nanoparticles demonstrated notable anticancer activity, achieving an IC<sub>50</sub> value of 13.3&#xa0;µg/mL, while exhibiting minimal cytotoxicity (only 11% reduction in viability) toward healthy fibroblast cells significantly less toxic than ZnO nanoparticles. These results suggest that chitosan and L-tartaric acid-functionalized ZnO nanoparticles hold promise for applications in both healthcare and industrial settings aimed at enhancing human well-being.</p>

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Exploring the Versatile Biocidal and Biocompatible Attributes of Chitosan-L-Tartaric Acid-Zinc Oxide Nanoparticles: Insights into Structural, Optical, and Biomedical Applications

  • 期刊论文

  • 发表日期：

    2025年6月26日

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  • Nidhi Srivastava,
  • Kavina Ganapathy,
  • Jaivik Pathak,
  • Srinivas Tadepalli

摘要

In response to the urgent need for safer and more effective antimicrobial and anticancer agents, this study aims to develop and evaluate biocompatible nanoparticles synthesized using green method, with enhanced therapeutic efficacy over conventional treatments. The present work focuses on synthesizing Azadirachta indica leaf extract-mediated zinc oxide (ZnO) and chitosan L-tartaric acid doped zinc oxide (ZnCsLT) NPs for its antibacterial, antifungal, and anticancer activity. XRD, DLS, FTIR, FESEM, EDAX, UV-Vis, PL, and XPS are the analytical techniqes used to characterize the synthesized ZnO and ZnCsLT NPs. The synthesized NPs exhibit wurtzite hexagonal structures, as confirmed by XRD studies. Nanoflake and spherical polyhedron structures were observed through HR-TEM and FESEM analysis. The elemental composition of the synthesized nanoparticles was confirmed through EDAX analysis. Antibacterial evaluation at a concentration of 2 µg/mL revealed that ZnCsLT nanoparticles exhibited superior activity compared to unmodified ZnO nanoparticles, with inhibition zones ranging between 14 and 16 mm against various bacterial strains. In vitro assessments of anticancer and cytotoxic effects were conducted using MDA-MB-237 human breast cancer cells and L929 fibroblast cells. The ZnCsLT nanoparticles demonstrated notable anticancer activity, achieving an IC50 value of 13.3 µg/mL, while exhibiting minimal cytotoxicity (only 11% reduction in viability) toward healthy fibroblast cells significantly less toxic than ZnO nanoparticles. These results suggest that chitosan and L-tartaric acid-functionalized ZnO nanoparticles hold promise for applications in both healthcare and industrial settings aimed at enhancing human well-being.