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<p>6-Mercaptopurine (6MP) commonly occurs in the treatment for acute lymphoblastic leukemia in children. The drug faces several limitations related to low bioavailability and short half-life. In order to overcome the drawbacks of conventional therapeutic systems for 6MP, innovative drug delivery systems are sought. The drug contains sulfur atoms capable of forming coordination bonds with metal ions, e.g., zinc. Hence, this study presented a bioactive glass doped with zinc ions as a carrier for 6MP. The research has demonstrated the carrier’s ability to sorption and then desorption as a controlled release. The drug is evenly distributed, suggesting that the doses released from it will always be similar. Drug release in a neutral environment is prolonged at controlled doses, while in an acidic environment, it is immediate. The viability of MCF-7 cells was significantly inhibited when treated with bioactive glass doped with zinc and 6MP. The results indicate the high potential of the material for use in targeted anticancer therapy.</p>

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Bioactive Glass Doped with Zinc Ions as a Carrier for 6-Mercaptopurine

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月4日

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  • Natalia Pyra,
  • Malgorzata Kucinska,
  • Marcel Jakubowski,
  • Łukasz Majchrzycki,
  • Zuzanna Buchwald,
  • Marek Murias,
  • Adam Voelkel,
  • Mariusz Sandomierski

摘要

6-Mercaptopurine (6MP) commonly occurs in the treatment for acute lymphoblastic leukemia in children. The drug faces several limitations related to low bioavailability and short half-life. In order to overcome the drawbacks of conventional therapeutic systems for 6MP, innovative drug delivery systems are sought. The drug contains sulfur atoms capable of forming coordination bonds with metal ions, e.g., zinc. Hence, this study presented a bioactive glass doped with zinc ions as a carrier for 6MP. The research has demonstrated the carrier’s ability to sorption and then desorption as a controlled release. The drug is evenly distributed, suggesting that the doses released from it will always be similar. Drug release in a neutral environment is prolonged at controlled doses, while in an acidic environment, it is immediate. The viability of MCF-7 cells was significantly inhibited when treated with bioactive glass doped with zinc and 6MP. The results indicate the high potential of the material for use in targeted anticancer therapy.