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<p>Hepatocellular carcinoma (HCC) remains a highly lethal cancer due to late-stage diagnosis and limited therapeutic options, necessitating advanced drug delivery systems. This work prepared a new drug delivery platform via producing a lead-based coordination polymer (CP1) [Pb(L)]<sub>n</sub> (1, where HL = 1&#xa0;H-1,2,4-triazole-5-carboxylic acid) via slow solvent evaporation and integrating it with polyvinyl alcohol (PVA) and 3-carboxypropyltriethoxysilane (CPTES). The PVA-CPTES composite system leverages PVA’s hydrophilicity and film-forming ability with CPTES’s functional silane groups, enhancing drug encapsulation, stability, and bioavailability. This system (PVA-CPTES@CP1@1) enabled efficient, controlled drug release, significantly inhibiting HCC cell proliferation by downregulating ENSA expression. The findings underscore the potential of the PVA-CPTES composite as a promising platform for targeted and sustained drug delivery in HCC therapy.</p>

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pH-Responsive Lead-Based Fluorescent Polymer Nanocarriers for ENSA-Targeted Drug Delivery and Hepatocellular Carcinoma Therapy

  • 期刊论文

  • 发表日期：

    2025年7月23日

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  • Lianxu Cai,
  • Sijin Que,
  • Mingbin Huang,
  • Weixun Wu

摘要

Hepatocellular carcinoma (HCC) remains a highly lethal cancer due to late-stage diagnosis and limited therapeutic options, necessitating advanced drug delivery systems. This work prepared a new drug delivery platform via producing a lead-based coordination polymer (CP1) [Pb(L)]n (1, where HL = 1 H-1,2,4-triazole-5-carboxylic acid) via slow solvent evaporation and integrating it with polyvinyl alcohol (PVA) and 3-carboxypropyltriethoxysilane (CPTES). The PVA-CPTES composite system leverages PVA’s hydrophilicity and film-forming ability with CPTES’s functional silane groups, enhancing drug encapsulation, stability, and bioavailability. This system (PVA-CPTES@CP1@1) enabled efficient, controlled drug release, significantly inhibiting HCC cell proliferation by downregulating ENSA expression. The findings underscore the potential of the PVA-CPTES composite as a promising platform for targeted and sustained drug delivery in HCC therapy.