<p>A new promising extractant of Benzoxazine type, namely Bis(4-Lauryl-3,4-dihydro-2H-1,3-benzoxazinyl) isopropane (B-dod), has been meticulously synthesized and effectively employed for the first time to extract uranium from the sulfate leach solution. Several characterizations, such as FTIR spectrometry, ¹H-NMR analysis, TGA analysis, and MS analysis, were performed to ensure its felicitous preparation. A series of extraction experiments were performed with B-dod synthesized extractant. From infrared data, the extraction was achieved, and the extractant bonded to the uranium through nitrogen and oxygen atoms in new Benzoxazine. Different factors affecting U extraction were studied. Using the slope analysis technique, we may infer that B-dod has extracted U as a complex with a 2:1 (U: B-dod) molar ratio. Extraction efficiencies of around 98% were achieved for U(VI), employing a concentration of 0.5% of B-dod extractant. The organic to aqueous ratio was 1:1, the aqueous pH was 3, and the contact period was 15&#xa0;min In addition, the B-dod can selectively extract U(VI) from other co-ions especially, rare earth. In two stages, as shown by the resulting McCabe-Thiele diagrams, U can be successfully extracted and stripped. Thermodynamic calculations showed that B-dod /U extraction is characterized by an exothermic nature. Uranium ions were stripped with 1&#xa0;M HNO₃, achieving 99.7% stripping efficiency. Finally, the principle of this technology can be applied to the treatment of ore sample through extraction of U from acidic ore leachate.</p>