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<p>Conventional scaffold designs often suffer from insufficient mechanical strength and limited antibacterial efficacy, hindering their clinical application in bone tissue engineering. To address these persistent challenges, polycaprolactone (PCL), tetracalcium phosphate (TTCP) and tetraneedlelike Zinc oxide whiskers (T-ZnOw) were used as raw materials, and triply periodic minimal surfaces design and selective laser sintering technology were used to prepare PCL/TTCP/T-ZnOw porous composite scaffolds. Thereinto, the tensile and bending strength of the composite scaffolds reached 18.69 and 6.79&#xa0;MPa, which were 3.57 and 1.75 times that of the PCL scaffold, respectively. More importantly, the composite scaffold demonstrated significant antibacterial effects in antibacterial experiments, while also demonstrating good biocompatibility. The synergistic effect of the TPMS structure and the functionalized composite materials enhances both the mechanical and biological properties of the scaffolds, making them a promising candidate for bone tissue regeneration applications.</p>

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Tetraneedlelike ZnO Whiskers/Tetracalcium Phosphate Synergistically Improved the Mechanical, Degradation and Biological Properties of Polycaprolactone Scaffolds

  • 期刊论文

  • 发表日期：

    2025年9月18日

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  • Yong Xu,
  • Peng Chen,
  • Xiaoping Guo,
  • Changfeng Li,
  • Zonghan Li,
  • Zixiong Zhou,
  • Mengqi Li,
  • Nanbiao Long,
  • Dongying Li

摘要

Conventional scaffold designs often suffer from insufficient mechanical strength and limited antibacterial efficacy, hindering their clinical application in bone tissue engineering. To address these persistent challenges, polycaprolactone (PCL), tetracalcium phosphate (TTCP) and tetraneedlelike Zinc oxide whiskers (T-ZnOw) were used as raw materials, and triply periodic minimal surfaces design and selective laser sintering technology were used to prepare PCL/TTCP/T-ZnOw porous composite scaffolds. Thereinto, the tensile and bending strength of the composite scaffolds reached 18.69 and 6.79 MPa, which were 3.57 and 1.75 times that of the PCL scaffold, respectively. More importantly, the composite scaffold demonstrated significant antibacterial effects in antibacterial experiments, while also demonstrating good biocompatibility. The synergistic effect of the TPMS structure and the functionalized composite materials enhances both the mechanical and biological properties of the scaffolds, making them a promising candidate for bone tissue regeneration applications.