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<p>Benzimidazoles and 2,3-dihydroquinazolin-4(1<i>H</i>)-ones are of great interest in medicinal chemistry for their potential to develop new therapeutic agents. This research presents an innovative one-pot synthesis method for these compounds using indium oxide nanoparticles (In<sub>2</sub>O<sub>3</sub> NPs) as a catalyst, which has shown consistent efficiency and reusability over seven cycles. Glycerol is used as an environmentally friendly solvent under mild conditions. The study demonstrates that various substituents on the benzene ring do not affect reaction efficiency, resulting in high product yields. Indium oxide nanoparticles outperform previous catalysts, often leading to lower yields and longer reaction times while less reusable. The catalyst was characterized using techniques such as FT-IR, BET, TEM, XRD, and TGA, confirming its retained activity after multiple uses.</p> Graphical Abstract <p></p>

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One-Pot, for the Green Preparation of Benzimidazoles and 2,3-Dihydroquinazolin-4(1H)-ones Catalyzed by In2O3 NPs/Glycerol

  • 期刊论文

  • 发表日期：

    2025年1月24日

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  • Fadhil Faez Sead,
  • Vicky Jain,
  • Anjan Kumar,
  • Subbulakshmi Ganesan,
  • Aman Shankhyan,
  • Girish Chandra Sharma,
  • Pushpa Negi Bhakuni,
  • Mosstafa Kazemi,
  • Ramin Javahershenas

摘要

Benzimidazoles and 2,3-dihydroquinazolin-4(1H)-ones are of great interest in medicinal chemistry for their potential to develop new therapeutic agents. This research presents an innovative one-pot synthesis method for these compounds using indium oxide nanoparticles (In2O3 NPs) as a catalyst, which has shown consistent efficiency and reusability over seven cycles. Glycerol is used as an environmentally friendly solvent under mild conditions. The study demonstrates that various substituents on the benzene ring do not affect reaction efficiency, resulting in high product yields. Indium oxide nanoparticles outperform previous catalysts, often leading to lower yields and longer reaction times while less reusable. The catalyst was characterized using techniques such as FT-IR, BET, TEM, XRD, and TGA, confirming its retained activity after multiple uses.

Graphical Abstract