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<p>In the present research, we have illustrated the straightforward provision of Au NPs interceded via lignosulfonate as an essential covering as well as decreasing factor under ultrasound irradiation. We studied constructing gold NPs reinstated through lignosulfonate (LS-Au Nanoparticles) and constructional features via UV–Vis, FT-IR, FE-SEM, TEM, EDX-elemental mapping and ICP-AES methods. The records indicated that lignosulfonate-covered gold NPs led to the least mean particle sizes of 20–30&#xa0;nm and globular forms of NPs. Furthermore, we decided to employ Suzuki–Miyaura coupling reactions to asses and measure the catalytic efficiency of the obtained LS-Au NPs composite. The prepared catalyst could quickly be reused more than 9 times in the catalytic experimentation process. It also enjoyed excellent practical capabilities and generalization for various aryl halides. The MTT test was used to evaluate the cytotoxic effects of the LS-Au NPs on GC1415 gastric cancer cells and normal human umbilical vein endothelial cells (HUVEC) during 48&#xa0;h. After being exposed to the LS-Au NPs, the cancer cell showed a reduction in viability, with an IC<sub>50</sub> value of 117&#xa0;µg/mL. A thorough analysis of the mTOR pathway revealed that the LS-Au NPs modulates the PI3K-Akt-mTOR pathway, which in turn affects apoptosis and cell growth in GC1415 cells. The route could be involved in the LS-Au NPs-induced apoptosis induction and cell cycle inhibition. In order to cure gastric cancer, the LS-Au NPs may prove to be a beneficial natural anti-cancer agent.</p>

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Ultrasound Assisted Green Synthesis of Lignosulfonate-Gold Nanocomposite (LS-Au NPs): The Study of Its Application in the Suzuki–Miyaura Coupling Reactions and Its Application for the Treatment of Gastric Cancer

  • 期刊论文

  • 发表日期：

    2025年1月10日

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  • Ran Wang,
  • Wei Ni,
  • Shuhua Fang,
  • Jie Chen,
  • Xiaoxu Fan

摘要

In the present research, we have illustrated the straightforward provision of Au NPs interceded via lignosulfonate as an essential covering as well as decreasing factor under ultrasound irradiation. We studied constructing gold NPs reinstated through lignosulfonate (LS-Au Nanoparticles) and constructional features via UV–Vis, FT-IR, FE-SEM, TEM, EDX-elemental mapping and ICP-AES methods. The records indicated that lignosulfonate-covered gold NPs led to the least mean particle sizes of 20–30 nm and globular forms of NPs. Furthermore, we decided to employ Suzuki–Miyaura coupling reactions to asses and measure the catalytic efficiency of the obtained LS-Au NPs composite. The prepared catalyst could quickly be reused more than 9 times in the catalytic experimentation process. It also enjoyed excellent practical capabilities and generalization for various aryl halides. The MTT test was used to evaluate the cytotoxic effects of the LS-Au NPs on GC1415 gastric cancer cells and normal human umbilical vein endothelial cells (HUVEC) during 48 h. After being exposed to the LS-Au NPs, the cancer cell showed a reduction in viability, with an IC50 value of 117 µg/mL. A thorough analysis of the mTOR pathway revealed that the LS-Au NPs modulates the PI3K-Akt-mTOR pathway, which in turn affects apoptosis and cell growth in GC1415 cells. The route could be involved in the LS-Au NPs-induced apoptosis induction and cell cycle inhibition. In order to cure gastric cancer, the LS-Au NPs may prove to be a beneficial natural anti-cancer agent.