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<p>Polyvinyl alcohol (PVA) - based Nitrogen-doped fluorescent polymer dots (PDs) have been synthesized via the one-pot hydrothermal carbonization of polyvinyl alcohol and Nitric acid. The resulting water-soluble fluorescent PDs have an average size of 2&#xa0;nm and exhibit excitation-dependent emission properties. Fluorescent PDs are used for sensing Sodium nitrate via fluorescence quenching of PDs in aqueous medium with a limit of detection ~ 26.75 nano-molar (nM). The as-synthesized polymer nanomaterials exhibited extremely low cytotoxicity in HEK 293 cells confirmed by MTT assay and showed dose-dependent toxicity, and this is employed as a candidate for cell imaging and the intracellular detection of sodium nitrate. The polymer nanomaterials were used as fluorescent probes for multicolour (red, green, and blue) imaging of HEK293 cell lines for the intracellular detection of Sodium nitrate.</p> Graphical Abstract <p></p>

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Polyvinyl Alcohol-Derived Biocompatible Polymer dot as an Intracellular Biomarker and Fluorescent Sensor

  • 期刊论文

  • 发表日期：

    2026年6月25日

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  • Aleena Ann Mathew,
  • Neethu Joseph,
  • Manoj Balachandran

摘要

Polyvinyl alcohol (PVA) - based Nitrogen-doped fluorescent polymer dots (PDs) have been synthesized via the one-pot hydrothermal carbonization of polyvinyl alcohol and Nitric acid. The resulting water-soluble fluorescent PDs have an average size of 2 nm and exhibit excitation-dependent emission properties. Fluorescent PDs are used for sensing Sodium nitrate via fluorescence quenching of PDs in aqueous medium with a limit of detection ~ 26.75 nano-molar (nM). The as-synthesized polymer nanomaterials exhibited extremely low cytotoxicity in HEK 293 cells confirmed by MTT assay and showed dose-dependent toxicity, and this is employed as a candidate for cell imaging and the intracellular detection of sodium nitrate. The polymer nanomaterials were used as fluorescent probes for multicolour (red, green, and blue) imaging of HEK293 cell lines for the intracellular detection of Sodium nitrate.

Graphical Abstract