Synthesis and Analysis of Magnetic Mg-Zn Nanoferrite Coated by Flavonoids: A Sophisticated Multifunctional Hybrid Nanocomposite for Biomedical Purposes

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发表日期：

2024年7月27日

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Zahraa S. Tahseen,
Baref Z. Rashid,
Sayran H. Haji,
Bryar E. Nuradeen,
Sewgil S. Anwer,
Rondik S. Abdullrahman,
Shiva S. Hasso,
Shagull S. Omar,
Abdulbari S. Othman,
Shameran Jamal Salih

摘要

Nanosized ferrites MgxZn_1 − xFe₂O₄ (0 < x < 1) were effectively synthesized using a wet ferritization method. The obtained spinel nanoparticles were then treated with flavonoids (Flv) extracted from agricultural waste of Punica Granatum L. and Allium cepa L. Various characterization techniques were utilized to analyze the surface morphology, magnetic properties, and elemental composition. The X-ray diffractograms revealed that the synthesized MgxZn_1 − xFe₂O₄ (MZFO) nanoparticles displayed a uniform cubic spinel structure, indicating the presence of a single phase. Morphological analysis revealed two distinct categories of MZFO nanoparticles: flower-shaped and plate-shaped particles. The attendance of Mg, Zn, O, Fe, and C elements in both MZFO and Flv/MZFO samples was confirmed by EDX analysis. TEM analysis further confirmed that each particle of the modified MZFO sample was a single crystal with an average particle size of 22 nm. Additionally, the modified MZFO nanoparticles exhibited a weight loss of 39.17% due to surface modification. Notably, the modified MZFO nanoparticles displayed a remarkable superparamagnetic behavior with a saturation magnetization of up to 41.875 emu/g. BET analysis demonstrated that the Flv/MZFO nanoparticles possessed a mesoporous structure with a total pore volume of 0.1349 cm³/g, an average pore size of 17.044 nm, and a specific surface area of 31.655 m²/g. The conjugated Flv/MZFO nanoferrites exhibited significant antibacterial efficacy, with inhibition zones of 7 mm and 8 mm against Gram-positive and Gram-negative bacteria, respectively. The minimum inhibitory concentration of the Flv/MZFO nanoferrites against S. aureus and E. coli was determined to be 0.156 mg/mL and 0.312 mg/mL, respectively. These results underscore the promising prospects of Flv/MZFO as cost-effective and safe nanomaterials in the field of biomedicine. Furthermore, they could potentially be employed as nanocarriers for magnetically targeted drug delivery in future applications.