Optimized Performance of PMMA Denture Base Material: Enhanced Mechanical, Biocompatibility, and Antibacterial Properties Modified with Extracted Jackfruit Latex Resin (Artocarpus Heterophyllus)

Jackfruit latex resin (JKF) is a cost effective, biocompatible and non-toxic natural polymer. Owing to the physical, thermal, mechanical, and biological properties of silicon (Si) particles as well as the biocompatibility and environmental safety of the naturally occurring polymeric component are a promising choice for the development of biomaterials. Few investigations on jackfruit latex based biocomposites were reported so far. This research intends to explore the physicochemical, morphological, and cytotoxic properties of Poly (methyl methacrylate) (PMMA) filled with extracted jackfruit latex resin. X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) was used to study the structural properties, differential scanning calorimetry (DSC) for thermal parameters, scanning electron microscopy (SEM) followed by energy-dispersive spectroscopy (EDS) for morphological as well as elemental analysis and particle size analyzer for particle size measurement. To check out the mechanical performances of the composites, the UTM machine was utilized. Further, to examine the biocompatibility (cytotoxicity and genotoxicity) of fabricated composites, the trypan blue assay, DAPI staining at Drosophila larvae, MTT assay of Osteoblast cells and antibacterial activity against Streptococcus pyogene, Bacillus cereus, Pseudomonas aeruginosa, Escherichia coli and Salmonella typhi bacteria were performed successfully.