Bimetallic Complexes: Fluorescence Performances and Loaded with Gel-Chinese Herb “Duhuo Jisheng Decoction” on Knee Osteoarthritis Rats
摘要
Two novel 3D bimetallic metal-organic frameworks (MOF) {Cd4Zn(L1)4(DMF)2[NH2(CH3)3]} (1) and {[Cd4Ca(L2)2(bipy)2(H2O)4]·(NO3)2} (2) have been successfully synthesized by using organic ligands {H3L1 = 4-[bis (4-carboxyphenyl) amino] benzoic acid; H4L2 = cyclopenta-1,4-diene-1,2,3,4-tetracarboxylic acid; bipy = 4-[2-(pyridin-4-yl) ethyl] pyridine; DMF: N,N-dimethylformamide} under solvothermal condition, which has been fully characterized by fluorescence spectroscopy, FTIR, single-XRD, EA, SEM, etc. Fluorescence tests were conducted with an excitation wavelength at 365 nm, and the results confirm the excellent photoluminescent performance of both compounds, suggesting their potential applications as green and blue fluorescence materials. Based on the unique advantages of this novel material, we utilized composite 1 as a drug carrier to load Duhuo Jisheng Decoction. Employing non-toxic, biocompatible hydrogel encapsulation, we constructed a novel hydrogel-organic framework composite. Through analyzing the impact of metal gel particles on SW1353 cells, we elucidated the regulatory role of miRNA-27a-3P on the PI3K/Akt/mTOR signaling pathway, indicating the system’s potential in inhibiting arthritis development and offering a new avenue for knee osteoarthritis treatment.