<p>Meaning in life (MIL) is an essential component of well-being, and social support is often considered an important way to enhance the MIL. This study explores the relationship between social support and meaning in life and its various indicators (presence of meaning, search for meaning, and purpose in life) through a meta-analysis. The analysis of 135 studies and 397 effect sizes found that there is a significant positive correlation between social support and MIL and its various indicators. Moderation analysis shows that the type of support moderates the relationship between social support and MIL. Specifically, the relationship between subjective social support and MIL is the strongest. Additionally, we found that region, individualism, sample type, age, gender, and the ratio of only children play inconsistent moderating roles in the relationship between social support and MIL and its various indicators. In summary, this study provides some empirical basis and theoretical inspiration for people to more effectively use social support to enhance the MIL.</p>