<p>This study investigates how the Industry 5.0 paradigm is transforming the real estate sector, giving rise to the emerging concept of Real Estate 5.0. As the industry shifts toward more sustainable, human-centered, and resilient systems, there is a growing need to conceptualize and better understand this new phase of digital transformation. To address this objective, the study employs a Systematic Literature Network Analysis (SLNA) that combines bibliometric mapping with a Systematic Literature Review (SLR). The bibliometric analysis is based on 249 publications from 2016 to 2025, retrieved from the Dimensions database. Using VOSviewer and the Bibliometrix R package, multiple bibliometric analyses were conducted to map the intellectual structure of Real Estate 5.0 research and to inform the subsequent Systematic Literature Review. The findings show that Real Estate 5.0 drives a strategic shift in the sector, characterized by the integrated use of advanced technologies to meet evolving user, environmental, and operational demands. Urban planning and smart cities emerge as an important research frontier, indicating that Real Estate 5.0 is gradually shifting from building-level digital applications toward more urban-oriented perspectives. Based on these bibliometric and systematic review findings, the study proposes a three-dimensional conceptual framework that formalizes Real Estate 5.0 through three core constructs—Human-Centered Real Estate (HCRE), Sustainable Real Estate Systems (SRES), and Resilient Real Estate Systems (RRES)—and synthesizes how key enabling technologies support each pillar across the real estate lifecycle.</p>