Purpose <p>This research sought to understand the perspectives of staff working in Violence Against Women (VAW) shelters in Ontario, Canada about implementing harm reduction approaches and their experiences with substance use practices in their shelters.</p> Methods <p>This project drew on qualitative data collected as part of a larger project examining harm reduction practices in VAW shelters. Semi-structured interviews with 25 staff at five VAW shelters in Ontario were analyzed.</p> Results <p>Results suggested that although staff reported that they were largely supportive of harm reduction practices, there was a wide range of perspectives about what harm reduction entails and how it works in practice. Safety of children, staff, and non-using women was raised as a key concern, but few actual safety-related occurrences were described. Further, many staff reported needing more training and education on harm reduction and substance use. They also reported that shelters need more resources, so they are better positioned to support women accessing their services.</p> Conclusion <p>Overall, the findings of this study indicate staff are supportive of integrating harm reduction practices in VAW shelters if it is done in a thoughtful way, is well-resourced, and supports the safety and well-being of all staff, women, and children onsite.</p>