Purpose <p>In response to the paucity of quantitative studies investigating the wellbeing of informal supporters, this study aimed to investigate the psychological and physiological wellbeing of informal supporters assisting survivors of intimate partner violence (IPV). It further sought to explore if mindful self-care and perceived social support predicted psychological distress among informal supporters.</p> Method <p>510 responses were received from IPV informal supporters and non-supporters. Participants completed the short version of the Depression, Anxiety, and Stress Scale, the Mindful Self-Care Scale, and the Multidimensional Scale of Perceived Social Support. Informal supporters also rated their psychological and physiological symptoms.</p> Results <p>Informal supporters reported experiencing psychological symptoms, including anger, helplessness, and anxiety, along with physiological symptoms of sleep difficulties and fatigue. Informal supporters also reported higher levels of psychological distress compared to both non-supporters and normative data. Among informal supporters, mindful self-care practices, particularly supportive relationships, and perceived social support emerged as significant predictors of lower distress levels.</p> Conclusions <p>The findings underscore the importance of assessing the psychological and physiological risks on informal supporters within network-oriented approaches to IPV prevention. Additionally, the protective role of mindful self-care and perceived social support are indicated. The results have implications for interventions to enhance informal supporter well-being and suggest the need for future research, particularly utilising longitudinal designs, to further explore these relationships and address limitations of the current design. This study represents the first known quantitative attempt to explore the risks associated with being an informal supporter and advocates for the promotion of self-care practices.</p>