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<p>Single-walled carbon nanotubes (SWCNTs) that emit fluorescence in the near-infrared region (NIR) enable the identification of certain molecules as a result of surface modification. In this study, a selective sensor system against dopamine, a neurotransmitter, was developed by wrapping a Guanine-Thymine-Adenine (GTA)<sub>20</sub>-repeat single-stranded DNA structure around SWCNT. Sensor analysis fluorescence measurements in the NIR region were performed using a customized microscope system. The fluorescence activity of the developed (GTA)<sub>20</sub>-SWCNT sensor against different biological samples was examined in the NIR region. It was observed that the sensor was selective against dopamine. In the study conducted in the 10–100 µM linear range, it was observed that an increase in fluorescence intensity occurred due to increasing dopamine (DA) concentration. The limit of detection (LOD) of the sensor was calculated as 4.2 × 10<sup>− 5</sup> M, and the significant limit of quantification (LOQ) was calculated as 13.24 × 10<sup>− 5</sup> M. With these features, the (GTA)<sub>20</sub>-SWCNT biosensor has the potential to be used as an innovative tool in DA detection.</p>

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Highly Selective Near-Infrared Nanosensors for Dopamine Detection: Leveraging the Phase–Engineered ssDNA-SWCNT Nanosensors

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月19日

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  • Ramazan Bayat,
  • Muhammed Bekmezci,
  • Damla Ikballi,
  • Iskender Isik,
  • Fatih Sen

摘要

Single-walled carbon nanotubes (SWCNTs) that emit fluorescence in the near-infrared region (NIR) enable the identification of certain molecules as a result of surface modification. In this study, a selective sensor system against dopamine, a neurotransmitter, was developed by wrapping a Guanine-Thymine-Adenine (GTA)20-repeat single-stranded DNA structure around SWCNT. Sensor analysis fluorescence measurements in the NIR region were performed using a customized microscope system. The fluorescence activity of the developed (GTA)20-SWCNT sensor against different biological samples was examined in the NIR region. It was observed that the sensor was selective against dopamine. In the study conducted in the 10–100 µM linear range, it was observed that an increase in fluorescence intensity occurred due to increasing dopamine (DA) concentration. The limit of detection (LOD) of the sensor was calculated as 4.2 × 10− 5 M, and the significant limit of quantification (LOQ) was calculated as 13.24 × 10− 5 M. With these features, the (GTA)20-SWCNT biosensor has the potential to be used as an innovative tool in DA detection.