Scholarlink

<p>In recent years, fluorescent sensors based on carbon quantum dots (CQDs) have been widely reported for pharmaceutical detection owing to their numerous advantages. In this study, a Fe³⁺-mediated fluorescence “off–on” sensor based on nitrogen-doped carbon quantum dots (N-CQDs) was developed for the selective detection of tiopronin (TPN). Briefly, highly fluorescent N-CQDs were synthesized via a one-step hydrothermal method using citric acid monohydrate and diethylenetriamine. XPS, FT-IR, UV-Vis, fluorescence spectroscopy, and DLS confirmed that the N-CQDs exhibit uniform size, aqueous stability, excitation-independent fluorescence, and a high quantum yield of 62.99%. Fe³⁺ selectively bound to N-CQDs to form a complex, resulting in fluorescence quenching. Subsequently, upon the addition of TPN, the fluorescence of N-CQDs showed a proportional recovery. During this process, the competitive coordination between TPN and Fe³⁺ led to the release of Fe³⁺ from the N-CQDs, thereby restoring the quenched fluorescence. The limit of detection (LOD) of TPN was 80 μmol/L, with a linear range of 0.2–0.7 mmol/L and an R² value of 0.9993. The content of TPN in enteric-coated tablets was quantified using this method, yielding recovery rates ranging from 92.59% to 104.22%. This method is simple, rapid, and reliable, offering good sensitivity without the need for expensive reagents or complex equipment.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

N-Doped CQDs as a Fluorescence Probe for Tiopronin Detection in Pharmaceutical Formulations via Static Quenching

  • 期刊论文

  • 发表日期：

    2026年4月15日

查看全文
  • Tianhui Liu,
  • Yiling Yan,
  • Zhenni Chen,
  • Chengfei Zhao

摘要

In recent years, fluorescent sensors based on carbon quantum dots (CQDs) have been widely reported for pharmaceutical detection owing to their numerous advantages. In this study, a Fe³⁺-mediated fluorescence “off–on” sensor based on nitrogen-doped carbon quantum dots (N-CQDs) was developed for the selective detection of tiopronin (TPN). Briefly, highly fluorescent N-CQDs were synthesized via a one-step hydrothermal method using citric acid monohydrate and diethylenetriamine. XPS, FT-IR, UV-Vis, fluorescence spectroscopy, and DLS confirmed that the N-CQDs exhibit uniform size, aqueous stability, excitation-independent fluorescence, and a high quantum yield of 62.99%. Fe³⁺ selectively bound to N-CQDs to form a complex, resulting in fluorescence quenching. Subsequently, upon the addition of TPN, the fluorescence of N-CQDs showed a proportional recovery. During this process, the competitive coordination between TPN and Fe³⁺ led to the release of Fe³⁺ from the N-CQDs, thereby restoring the quenched fluorescence. The limit of detection (LOD) of TPN was 80 μmol/L, with a linear range of 0.2–0.7 mmol/L and an R² value of 0.9993. The content of TPN in enteric-coated tablets was quantified using this method, yielding recovery rates ranging from 92.59% to 104.22%. This method is simple, rapid, and reliable, offering good sensitivity without the need for expensive reagents or complex equipment.

Graphical Abstract