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<p>We present a new coumarin-based chemodosimeter <b>1</b> that can be easily synthesized and used as a colorimetric and fluorescence sensor for selective detection of Cu<sup>2+</sup> in an aqueous solution. Chemodosimeter <b>1</b> is visual and fluorescence responses to a variety of different competing metal ions were also investigated. In an aqueous solution (DMSO/H<sub>2</sub>O = 9/1, v/v, buffered with HEPES pH = 7.4), Chemodosimeter <b>1</b> exhibits a selective response to Cu<sup>2+</sup> ions that is unique from other cations via diverse color changes and fluorescence enhancement. Chemodosimeter <b>1</b> may also be used to detect Cu<sup>2+</sup> ions selectively in vitro by creating a nice image of biological organelles using live-cell imaging fluorescence microscopy studies.</p>

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A new Easily Synthesized Coumarin-based Chemodosimeter for Fluorescent Imaging of Copper Ions in Living Cells

  • 期刊论文

  • 发表日期：

    2026年2月25日

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  • Yu-Kuan Chiang,
  • Shun-Yuan Luo,
  • Ratnnadeep Chandidas Sawant,
  • Twinkle S. Wankhede,
  • Yeshwant Ramchandra Bhorge

摘要

We present a new coumarin-based chemodosimeter 1 that can be easily synthesized and used as a colorimetric and fluorescence sensor for selective detection of Cu2+ in an aqueous solution. Chemodosimeter 1 is visual and fluorescence responses to a variety of different competing metal ions were also investigated. In an aqueous solution (DMSO/H2O = 9/1, v/v, buffered with HEPES pH = 7.4), Chemodosimeter 1 exhibits a selective response to Cu2+ ions that is unique from other cations via diverse color changes and fluorescence enhancement. Chemodosimeter 1 may also be used to detect Cu2+ ions selectively in vitro by creating a nice image of biological organelles using live-cell imaging fluorescence microscopy studies.