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<p>This study presents a novel ratiometric fluorescent silicon nanoparticles (LSiNPs) system for enantioselective recognition of tryptophan. The LSiNPs were synthesized by DAMO, rhodamine B and chiral ligand L-Lys via a one-pot method at room temperature. Upon increasing L-Trp concentration, the fluorescence intensity of the system at 440&#xa0;nm progressively enhanced while maintaining stability at 575&#xa0;nm, whereas D-Trp showed negligible effects. The sensor demonstrated an enantioselectivity coefficient of 11.7, enabling quantitative detection of L-Trp and determining enantiomeric composition in racemic mixtures. LSiNPs exhibits good selectivity towards L-Trp among 13 typical amino acid enantiomers. It can be applied to detect L-Trp in L-Tryptophan capsules rapidly and accurately. The recognition mechanism of tryptophan enantiomers was studied, indicating that the modification of chiral ligand L-Lys plays an important role in the recognition process. This work establishes a “turn-on” ratiometric strategy for chiral recognition of tryptophan enantiomers, offering new perspectives for enantiomer differentiation.</p>

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Chiral Ratiometric Fluorescent Silicon Nanoparticles for “Turn-on” Enantioselective Recognition of Tryptophan

  • 期刊论文

  • 发表日期：

    2026年2月7日

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  • Chen Liu,
  • Yaning Duan,
  • Cancan Lu,
  • Yu Fu,
  • Cuiling Ren,
  • Hongli Chen

摘要

This study presents a novel ratiometric fluorescent silicon nanoparticles (LSiNPs) system for enantioselective recognition of tryptophan. The LSiNPs were synthesized by DAMO, rhodamine B and chiral ligand L-Lys via a one-pot method at room temperature. Upon increasing L-Trp concentration, the fluorescence intensity of the system at 440 nm progressively enhanced while maintaining stability at 575 nm, whereas D-Trp showed negligible effects. The sensor demonstrated an enantioselectivity coefficient of 11.7, enabling quantitative detection of L-Trp and determining enantiomeric composition in racemic mixtures. LSiNPs exhibits good selectivity towards L-Trp among 13 typical amino acid enantiomers. It can be applied to detect L-Trp in L-Tryptophan capsules rapidly and accurately. The recognition mechanism of tryptophan enantiomers was studied, indicating that the modification of chiral ligand L-Lys plays an important role in the recognition process. This work establishes a “turn-on” ratiometric strategy for chiral recognition of tryptophan enantiomers, offering new perspectives for enantiomer differentiation.