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<p>In this study, a Zinc oxide/Tin dioxide/Carbon quantum dots nanocomposite (ZnO/SnO<sub>2</sub>/CQDs NCPs) was successfully synthesized and comprehensively characterized, and its application as a photoluminescence-based sensor for highly sensitive uric acid detection was explored. Individual nanoparticles of CQDs, ZnO, and SnO<sub>2</sub> were synthesized via a hydrothermal method, while the final composite was fabricated through a straightforward physical mixing approach. Characterization results obtained from UV–vis spectroscopy, XRD, TEM, and EDX analyses confirmed the structural integrity, morphology, and improved surface properties of the as-prepared nanocomposite. TEM images revealed that SnO<sub>2</sub> nanoparticles possessed an average diameter of ≈ 3&#xa0;nm, ZnO nanoparticles ≈ 50&#xa0;nm, and CQDs ≈ 22&#xa0;nm, with ZnO, SnO<sub>2</sub>, and CQDs randomly interconnected within the ZnO/SnO<sub>2</sub>/CQDs nanocomposites (ZnO/SnO<sub>2</sub>/CQDs NCPs). The sensing mechanism was governed by the “turn-on” photoluminescence phenomenon, arising from electron transfer between the excited nanocomposite and uric acid molecules. The fabricated sensor exhibited outstanding analytical performance, including an ultra-low limit of detection (LOD) of 0.085&#xa0;nM, an exceptionally wide linear detection range spanning from 10<sup>–13</sup>&#xa0;M to 0.1&#xa0;M, and a strong linear correlation coefficient (R<sup>2</sup> = 0.992) at&#xa0;the excitation wavelength of 420&#xa0;nm, attributed to the synergistic interactions among the components. These findings underscore the composite’s potential as a highly sensitive and reliable platform for uric acid detection. This work thus provides a simple, cost-effective, and promising strategy for clinical diagnostics and broader biomedical applications.</p> Graphical Abstract <p>Schematic illustration of the preparation process and sensing mechanism of ZnO/SnO<sub>2</sub>/CQDs nanocomposites (ZnO/SnO<sub>2</sub>/CQDs NCPs) for uric acid detection. Firstly, ZnO nanoparticles (ZnO NPs) and SnO<sub>2</sub> nanoparticles (SnO<sub>2</sub> NPs) were made using a hydrothermal method, while the carbon quantum dots (CQDs) were created with ascorbic acid as the carbon source. The ZnO/SnO<sub>2</sub>/CQDs nanocomposite was formed by physically mixing ZnO, SnO<sub>2</sub>, and CQDs dispersions. The inset photoluminescence (PL) spectra show a clear “turn-on” effect, where the PL intensity gradually increases with uric acid (UA) concentration from 10<sup>–13</sup> to 0.1&#xa0;M. This developed sensor has high sensitivity and a low detection limit (LOD = 0.085&#xa0;nM), showing its potential for clinical and biomedical uses.</p> <p></p>

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Synthesis of ZnO/SnO2/CQDs Nanocomposites and its Application in Uric Acid Detection by Photoluminescence Method

  • 期刊论文

  • 发表日期：

    2025年12月23日

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  • Tran Thi Bich Quyen,
  • Phu Nguyen Xuan Mai,
  • Nguyen Thanh Nha,
  • Tran Minh Khang,
  • Ngo Nguyen Tra My,
  • Bui Le Anh Tuan,
  • Luong Huynh Vu Thanh,
  • Duy Toan Pham

摘要

In this study, a Zinc oxide/Tin dioxide/Carbon quantum dots nanocomposite (ZnO/SnO2/CQDs NCPs) was successfully synthesized and comprehensively characterized, and its application as a photoluminescence-based sensor for highly sensitive uric acid detection was explored. Individual nanoparticles of CQDs, ZnO, and SnO2 were synthesized via a hydrothermal method, while the final composite was fabricated through a straightforward physical mixing approach. Characterization results obtained from UV–vis spectroscopy, XRD, TEM, and EDX analyses confirmed the structural integrity, morphology, and improved surface properties of the as-prepared nanocomposite. TEM images revealed that SnO2 nanoparticles possessed an average diameter of ≈ 3 nm, ZnO nanoparticles ≈ 50 nm, and CQDs ≈ 22 nm, with ZnO, SnO2, and CQDs randomly interconnected within the ZnO/SnO2/CQDs nanocomposites (ZnO/SnO2/CQDs NCPs). The sensing mechanism was governed by the “turn-on” photoluminescence phenomenon, arising from electron transfer between the excited nanocomposite and uric acid molecules. The fabricated sensor exhibited outstanding analytical performance, including an ultra-low limit of detection (LOD) of 0.085 nM, an exceptionally wide linear detection range spanning from 10–13 M to 0.1 M, and a strong linear correlation coefficient (R2 = 0.992) at the excitation wavelength of 420 nm, attributed to the synergistic interactions among the components. These findings underscore the composite’s potential as a highly sensitive and reliable platform for uric acid detection. This work thus provides a simple, cost-effective, and promising strategy for clinical diagnostics and broader biomedical applications.

Graphical Abstract

Schematic illustration of the preparation process and sensing mechanism of ZnO/SnO2/CQDs nanocomposites (ZnO/SnO2/CQDs NCPs) for uric acid detection. Firstly, ZnO nanoparticles (ZnO NPs) and SnO2 nanoparticles (SnO2 NPs) were made using a hydrothermal method, while the carbon quantum dots (CQDs) were created with ascorbic acid as the carbon source. The ZnO/SnO2/CQDs nanocomposite was formed by physically mixing ZnO, SnO2, and CQDs dispersions. The inset photoluminescence (PL) spectra show a clear “turn-on” effect, where the PL intensity gradually increases with uric acid (UA) concentration from 10–13 to 0.1 M. This developed sensor has high sensitivity and a low detection limit (LOD = 0.085 nM), showing its potential for clinical and biomedical uses.