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<p>A new Chemosensor, 5-ferrocenylsalicylaldehyde-2-pyridinehydrazone (<b>SP-Fc</b>), was designed and synthesized by condensing 5-ferrocenylsalicylaldehyde with 2-hydrazinopyridine. Its structure was characterized by <sup>1</sup>H NMR, <sup>13</sup>C NMR and HRMS. <b>SP-Fc</b> could be used to identify Al<sup>3+</sup> through dual optical and electrochemical responses. Upon addition of Al<sup>3+</sup>, The probe exhibited a significant fluorescence enhancement attributed to CHEF and the inhibition of both PET and ESIPT processes. The probe specifically regonized Al<sup>3 +</sup> in a wide pH range and had a well linear range (0-200 µM). Job’s plot analysis revealed that the interaction of <b>SP-Fc</b> with Al<sup>3+</sup> was 1:1 binding stoichiometry. The detection limit of probe for Al<sup>3+</sup> was observed as low as 1.30 × 10<sup>− 7</sup> M. The response mechanism of <b>SP-Fc</b> to Al<sup>3 +</sup> was confirmed through NMR titration experiment. Additionally, the electrochemical signals of <b>SP-Fc</b> in the presence of the Al<sup>3+</sup> was shifted significantly compared with those of the other metal cations tested. Moreover, Confocal fluorescence microscopy imaging demonstrated that <b>SP-Fc</b> can monitor Al<sup>3+</sup> in living MCF-7 cells with low cytotoxicity. This showcases <b>SP-Fc</b>’s promise for biological system and analytical chemistry, providing a robust tool for Al<sup>3 +</sup> detection in diverse settings.</p>

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A Novel, Dual-Response Chemosensor Based on Ferrocene Derivative for the Selective Detection of Al3+ Ions : Fluorescence and Electrochemical Signaling

  • 期刊论文

  • 发表日期：

    2025年12月16日

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  • Wenqin Liu,
  • Yanping Liu,
  • Zenghui Li,
  • Santai Zou,
  • Pingnan Wan,
  • Yan Lin

摘要

A new Chemosensor, 5-ferrocenylsalicylaldehyde-2-pyridinehydrazone (SP-Fc), was designed and synthesized by condensing 5-ferrocenylsalicylaldehyde with 2-hydrazinopyridine. Its structure was characterized by 1H NMR, 13C NMR and HRMS. SP-Fc could be used to identify Al3+ through dual optical and electrochemical responses. Upon addition of Al3+, The probe exhibited a significant fluorescence enhancement attributed to CHEF and the inhibition of both PET and ESIPT processes. The probe specifically regonized Al3 + in a wide pH range and had a well linear range (0-200 µM). Job’s plot analysis revealed that the interaction of SP-Fc with Al3+ was 1:1 binding stoichiometry. The detection limit of probe for Al3+ was observed as low as 1.30 × 10− 7 M. The response mechanism of SP-Fc to Al3 + was confirmed through NMR titration experiment. Additionally, the electrochemical signals of SP-Fc in the presence of the Al3+ was shifted significantly compared with those of the other metal cations tested. Moreover, Confocal fluorescence microscopy imaging demonstrated that SP-Fc can monitor Al3+ in living MCF-7 cells with low cytotoxicity. This showcases SP-Fc’s promise for biological system and analytical chemistry, providing a robust tool for Al3 + detection in diverse settings.