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<p>A fluorescent probe based on phthalic acid-<i>o</i>-phenylenediamine carbon dots (PP-CDs) was synthesized via a solvent-free method for the specific detection of oxytetracycline (OTC) in shellfish products. Characterization results revealed that the PP-CDs exhibit uniform morphology with an average size of 6.39 ± 1.37&#xa0;nm, high crystallinity, and abundant surface functional groups. Under optimized conditions, the PP-CDs showed high sensitivity to OTC through a static quenching mechanism, with a detection limit of 0.35 ng mL<sup>-1</sup> (0.76 nmol L<sup>-1</sup> ) and a linear range of 0.4 ~ 50 ng mL<sup>-1</sup>. Specificity experiments confirmed that the PP-CDs can selectively recognize OTC among 12 common veterinary drugs, including metronidazole and malachite green. Validation with real shellfish samples showed consistent results with high-performance liquid chromatography (HPLC), indicating the reliability of the method. This probe provides a rapid and cost-effective approach for monitoring OTC residues in seafood, which is of great significance for food safety and environmental protection.</p>

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Research on Carbon-Derived Fluorescent Probes for Selective Detection of Oxytetracycline in Shellfish Products

  • 期刊论文

  • 发表日期：

    2025年10月29日

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  • Ming Jiang,
  • Songyi Lin,
  • Xiaoliang Zheng,
  • Xiujuan Huang,
  • Hui Xu

摘要

A fluorescent probe based on phthalic acid-o-phenylenediamine carbon dots (PP-CDs) was synthesized via a solvent-free method for the specific detection of oxytetracycline (OTC) in shellfish products. Characterization results revealed that the PP-CDs exhibit uniform morphology with an average size of 6.39 ± 1.37 nm, high crystallinity, and abundant surface functional groups. Under optimized conditions, the PP-CDs showed high sensitivity to OTC through a static quenching mechanism, with a detection limit of 0.35 ng mL-1 (0.76 nmol L-1 ) and a linear range of 0.4 ~ 50 ng mL-1. Specificity experiments confirmed that the PP-CDs can selectively recognize OTC among 12 common veterinary drugs, including metronidazole and malachite green. Validation with real shellfish samples showed consistent results with high-performance liquid chromatography (HPLC), indicating the reliability of the method. This probe provides a rapid and cost-effective approach for monitoring OTC residues in seafood, which is of great significance for food safety and environmental protection.